Association of Immune Thrombocytopenia and Inflammatory Bowel Disease in Children

The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Clinical characteristics of both IB...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-04, Vol.10 (9), p.1940
Main Authors: Guarina, Angela, Barone, Angelica, Tornesello, Assunta, Marinoni, Maddalena, Lassandro, Giuseppe, Giordano, Paola, Motta, Milena, Spinelli, Marco, Fontanili, Ilaria, Giona, Fiorina, Menna, Francesco, Chiocca, Elena, Fotzi, Ilaria, Petrone, Angelamaria, Graziano, Francesco, Saracco, Paola, Puccio, Giuseppe, Citrano, Michele, Russo, Giovanna, Farruggia, Piero
Format: Article
Language:English
Subjects:
Anemia
Antigens
Autoimmune diseases
Blood diseases
Blood platelets
Clinical medicine
Hematology
Inflammatory bowel disease
Lupus
Patients
Pediatrics
Thrombocytopenia
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Summary:The association between inflammatory bowel disease (IBD) and immune thrombocytopenia (ITP) is still uncertain. In this multicenter retrospective study, the coexistence of both diseases was investigated in children diagnosed from 1 January 2000 to 31 December 2019. Clinical characteristics of both IBD and ITP, onset of disorders, and patient's response to treatment were collected through a structured form sent to 55 Italian pediatric referring centers for hematological disorders. Centers responded to the survey and reported the coexistence of IBD and ITP in 14 children. The first diagnosis was ITP in 57.1% and IBD in 35.7% of patients: it was simultaneous in 7.1%. IBD was classified as ulcerative colitis (57.1%), Crohn disease (35.7%), and unclassified (7.1%). No therapy for IBD other than steroids had any effect on ITP course. Colectomy resulted in recovery from ITP in 1 of the 2 patients surgically treated. ITP was always mild but turned to be chronic in half of patients. In all patients, ITP was mild without any evident impact on IBD severity, but the incidence of chronic ITP seems to be higher than what is usually observed in the pediatric age group. Colectomy had unpredictable effects on ITP.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10091940