Racial Differences in Population Attributable Risk for Epithelial Ovarian Cancer in the OCWAA Consortium

Abstract Background The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. Methods We used data from 4 case-contro...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 2021-06, Vol.113 (6), p.710-718
Main Authors: Peres, Lauren C, Bethea, Traci N, Camacho, Tareq F, Bandera, Elisa V, Beeghly-Fadiel, Alicia, Chyn, Deanna L, Harris, Holly R, Joslin, Charlotte E, Moorman, Patricia G, Myers, Evan, Ochs-Balcom, Heather M, Rosenow, Will, Setiawan, V Wendy, Wu, Anna H, Rosenberg, Lynn, Schildkraut, Joellen M
Format: Article
Language:English
Subjects:
African Americans
Aspirin
Body mass
Body mass index
Body size
Breast cancer
Carcinoma, Ovarian Epithelial - complications
Carcinoma, Ovarian Epithelial - epidemiology
Case-Control Studies
Confidence intervals
Consortia
Contraceptives
Female
Genetics
Health risks
Humans
Oral contraceptives
Ovarian cancer
Ovarian Neoplasms - epidemiology
Ovarian Neoplasms - etiology
Prospective Studies
Race
Race Factors
Racial differences
Risk analysis
Risk Factors
Statistical analysis
Statistical tests
White people
Womens health
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Summary:Abstract Background The causes of racial disparities in epithelial ovarian cancer (EOC) incidence remain unclear. Differences in the prevalence of ovarian cancer risk factors may explain disparities in EOC incidence among African American (AA) and White women. Methods We used data from 4 case-control studies and 3 case-control studies nested within prospective cohorts in the Ovarian Cancer in Women of African Ancestry Consortium to estimate race-specific associations of 10 known or suspected EOC risk factors using logistic regression. Using the Bruzzi method, race-specific population attributable risks (PAR) were estimated for each risk factor individually and collectively, including groupings of exposures (reproductive factors and modifiable factors). All statistical tests were 2-sided. Results Among 3244 White EOC cases and 9638 controls and 1052 AA EOC cases and 2410 controls, AA women had a statistically significantly higher PAR (false discovery rate [FDR] P 
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/djaa188