Open-loop Audio-Visual Stimulation for sleep promotion in older adults with comorbid insomnia and osteoarthritis pain: results of a pilot randomized controlled trial

• Published in: Sleep medicine 2021-06, Vol.82, p.37-42
• Main Authors: Tang, Hsin-Yi (Jean), McCurry, Susan M., Pike, Kenneth C., Riegel, Barbara, Vitiello, Michael V.
• Format: Article
• Language: English
• Subjects: Aged; Audio-visual stimulation (AVS); Depression; Humans; Insomnia; Middle Aged; Osteoarthritis; Osteoarthritis - complications; Osteoarthritis - therapy; Pain; Photic Stimulation; Pilot Projects; Sleep; Sleep Initiation and Maintenance Disorders - epidemiology; Sleep Initiation and Maintenance Disorders - therapy; Treatment Outcome
• ISSN: 1389-9457; 1878-5506
• DOI: 10.1016/j.sleep.2021.03.025

Osteoarthritis is commonly comorbid with insomnia in older adults. While cognitivebehavioral therapy for insomnia is the recommended first-line treatment for insomnia, alternative efficacious non-pharmacological options are needed. This study examined sleep and pain in 30 community-dwelling older adults with comorbid insomnia and osteoarthritis pain randomized to two weeks of 30 min of bedtime active (n = 15, mean age 66.7 ± 5.2) or placebo control (n = 15, mean age 68.9 ± 5.0) Audiovisual Stimulation (AVS). After AVS use, improvements in sleep, pain, and depression were reported for both groups but between-group comparisons were non-significant. A posthoc analysis examined the effects of AVS in the 11 subjects who reported sleep latency complaints (≥30 min). No significant group differences were found for this small sleep latency subsample; however, the pre-post effect sizes (ES) of active AVS versus placebo were greatly increased for the subsample relative to the total sample for sleep (ES = 0.41 versus 0.18 for the Insomnia Severity Index, and 0.60 versus 0.03 for the Pittsburgh Sleep Quality Index, respectively). A similar enhanced effect pattern was found for pain (ES = 0.41 versus 0.15 for the Brief Pain Inventory). Study findings suggest that the 30-min AVS program may have potential to improve sleep in older adults with sleep onset but not sleep maintenance difficulty. Despite study limitations of a small sample size and lack of follow-up, results offer valuable insights into the functionality of AVS treatment. Future research should focus on subjects with sleep onset complaints, who are most likely to receive benefit from this treatment modality. •Using a 30-min delta-brainwave-induced AVS program has the potential to improve sleep.•AVS is likely to be most beneficial with sleep onset but not sleep maintenance difficulties.•After two-week of AVS use, improvements in sleep, pain, and depression were observed.