GRASP55 Senses Glucose Deprivation through O-GlcNAcylation to Promote Autophagosome-Lysosome Fusion

The Golgi apparatus is the central hub for protein trafficking and glycosylation in the secretory pathway. However, how the Golgi responds to glucose deprivation is so far unknown. Here, we report that GRASP55, the Golgi stacking protein located in medial- and trans-Golgi cisternae, is O-GlcNAcylate...

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Bibliographic Details
Published in:	Developmental cell 2018-04, Vol.45 (2), p.245-261.e6
Main Authors:	Zhang, Xiaoyan, Wang, Leibin, Lak, Behnam, Li, Jie, Jokitalo, Eija, Wang, Yanzhuang
Format:	Article
Language:	English
Subjects:	Acetylglucosamine - metabolism autophagosome-lysosome fusion Autophagosomes - metabolism Autophagy Endosomes - metabolism Glucose - deficiency glucose starvation Golgi Golgi Apparatus - metabolism Golgi Matrix Proteins Golgi stacking proteins GRASP55 HeLa Cells Humans LAMP2 LC3 Lysosomes - metabolism Membrane Proteins - metabolism O-GlcNAcylation Protein Processing, Post-Translational Protein Transport tethering
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