Clinico-Laboratory Features and Associated Factors of Lupus Mesenteric Vasculitis

Introduction Lupus mesenteric vasculitis (LMV) is a rare but potentially life-threatening clinical entity in systemic lupus erythematosus (SLE) patients. Objective The present study was initiated to explore the clinical features and associated factors of LMV in SLE patients. Methods We conducted a r...

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Bibliographic Details
Published in:Rheumatology and therapy. 2021-06, Vol.8 (2), p.1031-1042
Main Authors: Wang, Hongxu, Gao, Qing, Liao, Guanyi, Ren, Sirui, You, Wenxian
Format: Article
Language:English
Subjects:
Family Medicine
General Practice
Internal Medicine
Lupus
Medicine
Medicine & Public Health
Original Research
Orthopedics
Quality of Life Research
Rheumatology
Ulcers
Urogenital system
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Summary:Introduction Lupus mesenteric vasculitis (LMV) is a rare but potentially life-threatening clinical entity in systemic lupus erythematosus (SLE) patients. Objective The present study was initiated to explore the clinical features and associated factors of LMV in SLE patients. Methods We conducted a retrospective study on 50 cases of SLE patients with lupus mesenteric vasculitis (LMV) from January 2010 to December 2019 and 89 cases of non-LMV-SLE patients with similar demographic and comorbidities were included as control. All the data regarding clinical features, laboratory findings, and treatment were reviewed independently by two experts in the field. Both univariate and multivariate logistic regression analyses were employed to identify the associated factors of LMV. Results The incidence of LMV was 2.9% among hospitalized SLE patients in the current study. The most frequent symptom and physical sign of LMV were respectively abdominal pain (48, 96%) and abdominal tenderness (45, 90%). Through univariate and subsequent multivariate analysis, oral ulcer (OR, 4.25; P  = 0.024), urinary tract involvement (OR, 5.23; P  = 0.021), and elevated D-dimer (OR, 1.121; P  = 0.008) were demonstrated to be positively associated with LMV, while percentage of lymphocytes (OR, 0.928; P  = 0.004) and complement 3 (OR, 0.048; P  = 0.008) were negatively correlated with LMV. Conclusions Oral ulcer, urinary tract involvement, reduced percentage of lymphocytes and complement 3, elevated D-dimer could be associated factors for LMV in SLE patients.
ISSN:2198-6576
2198-6584
DOI:10.1007/s40744-021-00323-x