Outpatient Fluoroquinolone Prescription Fills in the United States, 2014 to 2020: Assessing the Impact of Food and Drug Administration Safety Warnings

The impact of United States Food and Drug Administration (FDA) safety warnings on outpatient fluoroquinolone use is unclear. Annual changes in outpatient ciprofloxacin, levofloxacin, and moxifloxacin prescription fills (IQVIA National Prescription Audit databases) were assessed using a regression mo...

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Bibliographic Details
Published in:Antimicrobial agents and chemotherapy 2021-06, Vol.65 (7), p.e0015121-e0015121, Article e0015121
Main Authors: Buehrle, Deanna J, Wagener, Marilyn M, Clancy, Cornelius J
Format: Article
Language:English
Subjects:
Clinical Therapeutics
Drug Prescriptions
Fluoroquinolones - adverse effects
Humans
Levofloxacin
Outpatients
United States
United States Food and Drug Administration
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Summary:The impact of United States Food and Drug Administration (FDA) safety warnings on outpatient fluoroquinolone use is unclear. Annual changes in outpatient ciprofloxacin, levofloxacin, and moxifloxacin prescription fills (IQVIA National Prescription Audit databases) were assessed using a regression model. Monthly fills during baseline (August 2014 to April 2016) and first (May 2016 to June 2018) and second FDA warning periods (July 2018 to February 2020) were compared by interrupted time series analysis. From 2015 through 2019, total fluoroquinolone fills decreased from 35,616,786 (111.1/1,000 persons) to 21,100,050 (64.3/1,000 persons) annually (10.8% annually [  = 0.001]). Ciprofloxacin, levofloxacin, and moxifloxacin fills decreased annually by 10.4% ( 0.001), 11.2% ( 0.001), and 17.7% ( 0.008), respectively. During the baseline period, there was no significant change in monthly fluoroquinolone fills. In May 2016 and during the first warning period, monthly fluoroquinolone fills decreased significantly (  
ISSN:0066-4804
1098-6596
DOI:10.1128/aac.00151-21