Snapshot photoacoustic topography through an ergodic relay for high-throughput imaging of optical absorption

Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic topography through an ergodic relay (PATER) f...

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Bibliographic Details
Published in:Nature photonics 2020-03, Vol.14 (3), p.164-170
Main Authors: Li, Yang, Li, Lei, Zhu, Liren, Maslov, Konstantin, Shi, Junhui, Hu, Peng, Bo, En, Yao, Junjie, Liang, Jinyang, Wang, Lidai, Wang, Lihong V.
Format: Article
Language:English
Subjects:
631/1647/245/2226
639/624/1107/510
639/624/1111/55
Applied and Technical Physics
Biomedical materials
Ergodic processes
Flow velocity
Hemodynamic responses
Image resolution
Low cost
Melanoma
Neuroimaging
Physics
Physics and Astronomy
Pulse propagation
Quantum Physics
Relay
Spatial data
Topography
Tumors
Ultrasonic testing
Ultrasonic transducers
Wave propagation
Wearable technology
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Summary:Current embodiments of photoacoustic imaging require either serial detection with a single-element ultrasonic transducer or parallel detection with an ultrasonic array, necessitating a trade-off between cost and throughput. Here, we present photoacoustic topography through an ergodic relay (PATER) for low-cost high-throughput snapshot wide-field imaging. Encoding spatial information with randomized temporal signatures through ergodicity, PATER requires only a single-element ultrasonic transducer to capture a wide-field image with a single laser shot. We applied PATER to demonstrate both functional imaging of haemodynamic responses and high-speed imaging of blood pulse wave propagation in mice in vivo. Leveraging the high frame rate of 2 kHz, PATER tracked and localized moving melanoma tumour cells in the mouse brain in vivo, which enabled flow velocity quantification and super-resolution imaging. Among the potential biomedical applications of PATER, wearable devices to monitor human vital signs in particular is envisaged. A low-cost high-throughput photoacoustic imaging based on an ergodic relay coupled with a single-element ultrasonic transducer that can capture a wide-field image with only a single laser shot is demonstrated.
ISSN:1749-4885
1749-4893
DOI:10.1038/s41566-019-0576-2