Chronically elevated depressive symptoms interact with acute increases in inflammation to predict worse neurocognition among people with HIV

We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing sp...

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Bibliographic Details
Published in:Journal of neurovirology 2021-02, Vol.27 (1), p.160-167
Main Authors: Saloner, Rowan, Paolillo, Emily W., Heaton, Robert K., Grelotti, David J., Stein, Murray B., Miller, Andrew H., Atkinson, J. Hampton, Letendre, Scott L., Ellis, Ronald J., Grant, Igor, Iudicello, Jennifer E., Moore, David J.
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-HIV Agents - therapeutic use
Biomedical and Life Sciences
Biomedicine
C-Reactive Protein - metabolism
Cognition
Cognitive Dysfunction - virology
Depression - etiology
Female
HIV Infections - complications
HIV Infections - drug therapy
Humans
Immunology
Infectious Diseases
Inflammation
Longitudinal Studies
Male
Middle Aged
Neurology
Neurosciences
Short Communication
Virology
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Summary:We examined the joint effects of depressive symptoms (Beck Depression Inventory-II (BDI-II)) and systemic inflammation (plasma C-reactive protein (CRP)) on longitudinal profiles of neurocognition in a cohort of 143 people with HIV (PWH) on antiretroviral therapy. Global neurocognition, processing speed, motor skills, and attention/working memory all worsened as CRP increased but only among PWH who, on average, exhibited moderate to severe depressive symptoms (BDI-II > 22). Findings suggest that some PWH with chronically elevated depressive symptoms may have an inflammatory subtype of depression and a particular vulnerability to neurocognitive changes that may respond to drugs targeting inflammation or its neural sequelae.
ISSN:1355-0284
1538-2443
1538-2443
DOI:10.1007/s13365-020-00925-1