Sperm Parameters Before and After COVID-19 mRNA Vaccination

Two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), received Emergency Use Authorization from the US Food and Drug Administration. Despite high efficacy and few adverse events found in clinical trials, only 56% of individuals in the US reported wanting to receive the vaccine. One...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2021-07, Vol.326 (3), p.273-274
Main Authors: Gonzalez, Daniel C, Nassau, Daniel E, Khodamoradi, Kajal, Ibrahim, Emad, Blachman-Braun, Ruben, Ory, Jesse, Ramasamy, Ranjith
Format: Article
Language:English
Subjects:
Adult
Adverse events
Clinical trials
Comments
Coronaviruses
COVID-19
COVID-19 vaccines
COVID-19 Vaccines - adverse effects
Fertility
Fertility - drug effects
Humans
Immunization
Informed consent
Letter
Letters
Male
mRNA
mRNA Vaccines
Online First
Parameters
Prospective Studies
Research Letter
Semen Analysis
Sperm
Sperm Count
Vaccines
Vaccines, Synthetic - adverse effects
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Summary:Two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), received Emergency Use Authorization from the US Food and Drug Administration. Despite high efficacy and few adverse events found in clinical trials, only 56% of individuals in the US reported wanting to receive the vaccine. One of the reasons for vaccine hesitancy is the potential negative effect on fertility. This single-center prospective study at the University of Miami recruited healthy volunteers aged 18 to 50 years scheduled for mRNA COVID-19 vaccination through flyers posted throughout the university hospital and internal list-serve emails. The University of Miami institutional review board approved the study and written informed consent was obtained from all participants. In this study of sperm parameters before and after 2 doses of a COVID-19 mRNA vaccine, there were no significant decreases in any sperm parameter among this small cohort of healthy men.
ISSN:0098-7484
1538-3598
1538-3598
DOI:10.1001/jama.2021.9976