Clinical implementation of algorithm-based embryo selection is associated with improved pregnancy outcomes in single vitrified warmed euploid embryo transfers

Purpose To assess whether utilization of a mathematical ranking algorithm for assistance with embryo selection improves clinical outcomes compared with traditional embryo selection via morphologic grading in single vitrified warmed euploid embryo transfers (euploid SETs). Methods A retrospective coh...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2021-07, Vol.38 (7), p.1647-1653
Main Authors: Friedenthal, Jenna, Hernandez-Nieto, Carlos, Roth, Rose Marie, Slifkin, Richard, Gounko, Dmitry, Lee, Joseph A., Nazem, Taraneh, Briton-Jones, Christine, Copperman, Alan
Format: Article
Language:English
Subjects:
Adult
Algorithms
Assisted Reproduction Technologies
Automation
Birth rate
Blastocyst - cytology
Blastocyst - physiology
Decision Making, Computer-Assisted
Embryo Implantation
Female
Gynecology
Human Genetics
Humans
Implantation
Medicine
Medicine & Public Health
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Reproductive Medicine
Retrospective Studies
Single Embryo Transfer - methods
Vitrification
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Summary:Purpose To assess whether utilization of a mathematical ranking algorithm for assistance with embryo selection improves clinical outcomes compared with traditional embryo selection via morphologic grading in single vitrified warmed euploid embryo transfers (euploid SETs). Methods A retrospective cohort study in a single, academic center from September 2016 to February 2020 was performed. A total of 4320 euploid SETs met inclusion criteria and were included in the study. Controls included all euploid SETs in which embryo selection was performed by a senior embryologist based on modified Gardner grading (traditional approach). Cases included euploid SETs in which embryo selection was performed using an automated algorithm-based approach (algorithm-based approach). Our primary outcome was implantation rate. Secondary outcomes included ongoing pregnancy/live birth rate and clinical loss rate. Results The implantation rate and ongoing pregnancy/live birth rate were significantly higher when using the algorithm-based approach compared with the traditional approach (65.3% vs 57.8%, p
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-021-02203-3