Impact of Sickle Cell Trait on Morbidity and Mortality from Sars-Cov-2 Infection

• Published in: Blood 2020-11, Vol.136 (Supplement 1), p.31-32
• Main Authors: Merz, Lauren E., Mistry, Kavita, Freedman, Revital, Jolley, Katherine L, Park, Hae Soo, Dorfman, David M., Neuberg, Donna S., Achebe, Maureen
• Format: Article
• Language: English
• ISSN: 0006-4971; 1528-0020
• DOI: 10.1182/blood-2020-142835

Introduction: The high morbidity and mortality of SARS-CoV-2 in Blacks or African American in the United States is well established. Individuals with sickle cell trait (SCT), who are mostly Black or African American, have adverse health outcomes in situations of increased physiologic stress. The novel corona virus SARS-CoV-2 causes a severe multi-systemic viral infection that induces intense inflammation and metabolic derangements that can exacerbate RBC sickling and organ damage. The purpose of this study is to evaluate the impact of SCT status on the outcome of patients hospitalized for SARS-CoV-2. Methods: We conducted a multi-center, IRB-approved, retrospective analysis of Black/African American patients who were admitted for management of SARS-CoV-2 infection from March 24, 2020 to June 2, 2020. Patients were identified using an electronic medical record (EMR) report that selected for race as “Black or African American” and a positive SARS-CoV-2 PCR test during that admission. We excluded patients admitted for reasons other than SARS-CoV-2 infection and reviewed only the in-hospital experience. Patient demographics, co-morbidities, admission laboratory values, complications of SARS-CoV-2 infection, and status on discharge were abstracted by manual chart review. High performance liquid chromatography (HPLC) was performed on discarded blood of patients to test for sickle cell trait. The primary objective was to evaluate the impact of SCT status on morbidity outcomes of Blacks/African Americans hospitalized with SARS-CoV-2 infection. Categorical data were tested using the Fisher exact test, and quantitative data were tested using the Wilcoxon rank sum test. Testing was done at the nominal 0.05 two-sided significance level. Results: One hundred and sixty-six Black or African American patients admitted for SARS-CoV-2 infection are included in the analysis. Twenty patients had SCT, 143 had normal hemoglobin (AA) and 3 had hemoglobin C trait (AC). The 146 patients with AA and AC hemoglobin were pooled together. Patient demographics, comorbidities, and lab values on admission by SCT status are shown in Table 1. Complications of SARS-CoV-2 by SCT status is shown in Table 2. Among Black or African American patients admitted for SARS-CoV-2 in this study, SCT represented 12.0% of the total. At the time of admission, individuals with SCT had significantly higher creatinine (p=0.004) but were less likely to present with a history of chronic lung disease (p=0.004).