Validation of measurement scores for evaluating vascular anomaly skin lesions

Vascular anomalies comprise a heterogeneous group of disorders caused by abnormal proliferation or development of vascular and/or lymphatic vessels. Vascular anomalies present with various symptoms and complications, but no standardized methods evaluate their severity, and to measure treatment outco...

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Bibliographic Details
Published in:Journal of dermatology 2021-07, Vol.48 (7), p.993-998
Main Authors: Yasue, Shiho, Ozeki, Michio, Endo, Saori, Ishihara, Takuma, Nishiguchi‐Kurimoto, Mana, Jinnin, Masatoshi, Kawamura, Miho, Seishima, Mariko, Ohnishi, Hidenori
Format: Article
Language:English
Subjects:
Color
Coloration
Dermatology
disease scoring system
drug treatment
lymphatic malformation
Lymphatic system
Original
Physical examinations
Sarcoma
Skin diseases
Skin lesions
Tumors
vascular tumor
Vein & artery diseases
venous malformation
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Description
Summary:Vascular anomalies comprise a heterogeneous group of disorders caused by abnormal proliferation or development of vascular and/or lymphatic vessels. Vascular anomalies present with various symptoms and complications, but no standardized methods evaluate their severity, and to measure treatment outcomes is difficult. To assess the responsiveness of measurement scores for evaluating vascular anomaly skin lesions, we conducted a validation study to compare these measurement scores with patients’ objective data. In this study, data were collected from treated and untreated patients. Skin lesions were photographed at baseline and after a follow‐up period of 3–6 months. The volume of skin lesions, the degree of red or purple coloration, and color tone were measured objectively. Two external dermatologists evaluated patients’ photographs and determined scores, which represented criteria for improvements in skin lesions (size and color) and 6‐point Physician Global Assessment scores. The correlation between these scores and patients’ objective data (lesion volume and color) was assessed to validate the scores. Twenty‐three cases of vascular anomaly (seven vascular tumors, five lymphatic malformations, three venous malformations, and eight lymphatic–venous malformations) were examined. Scores for improvements in vascular anomaly skin lesions (size and color) correlated with a change in lesion volume, the degree of red or purple coloration, color tone score, and 6‐point Physician Global Assessment score. Our findings suggest that these measurement scores are responsive to changes in vascular anomaly skin lesions after observation.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.15839