Osteopontin, GLUT1 and Ki‐67 expression in malignant peritoneal mesothelioma: prognostic implications

Background Malignant peritoneal mesothelioma is the most common primary peritoneal neoplasm. The only universally recognised pathological prognostic factor is histopathological subtype. Prognostic markers based on patient features and clinical stages have been disappointing. Aims To assess the progn...

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Bibliographic Details
Published in:Internal medicine journal 2021-06, Vol.51 (6), p.896-904
Main Authors: Liu, Yingying, Zheng, Guoqi, Yang, Dongliang, Guo, Xiaozhong, Tian, Liang, Song, Hui, Liang, Yufei
Format: Article
Language:English
Subjects:
Chemotherapy
GLUT1
immunohistochemistry
Ki‐67
Labeling
Mesothelioma
Multivariate analysis
Original
Osteopontin
Patients
peritoneal mesothelioma
Peritoneum
Statistical analysis
Surgery
survival
Tumors
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Summary:Background Malignant peritoneal mesothelioma is the most common primary peritoneal neoplasm. The only universally recognised pathological prognostic factor is histopathological subtype. Prognostic markers based on patient features and clinical stages have been disappointing. Aims To assess the prognostic role of several clinicopathological features in a retrospective cohort of 60 patients diagnosed with peritoneal mesothelioma. Methods Sixty patients were centrally collected and were immunohistochemically analysed for the expression of osteopontin (OPN), GLUT1 and Ki‐67. Labelling was assessed by two pathologists. Complete clinical information and follow‐up were obtained from patients' records. Results OPN expression was identified in 52 (86.6%) of 60 specimens, and GLUT1 in 39 (65%) of 60 specimens. Univariate Cox regression analysis showed that a lower peritoneal carcinomatosis index (PCI), tumour‐directed treatment (chemotherapy or surgery alone or in any combination), lower Ki‐67, GLUT1 and lower OPN expression had a statistically significant positive effect on overall survival (OS). PCI (hazard ratio (HR) = 1.032 (95% confidence interval (CI): 1.000–1.067); P = 0.054) and tumour‐directed treatment (HR = 0.211 (95% CI: 0.104–0.430); P
ISSN:1444-0903
1445-5994
DOI:10.1111/imj.14936