Genome-Wide Association Study Identifies 12 Loci Associated with Body Weight at Age 8 Weeks in Korean Native Chickens

Meat from Korean native chickens (KNCs) has high consumer demand; however, slow growth performance and high variation in body weight (BW) of KNCs remain an issue. Genome-wide association study (GWAS) is a powerful method to identify quantitative trait-associated genomic loci. A GWAS, based on a larg...

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Bibliographic Details
Published in:Genes 2021-07, Vol.12 (8), p.1170
Main Authors: Cha, Jihye, Choo, Hyojun, Srikanth, Krishnamoorthy, Lee, Seung-Hwan, Son, Ju-Whan, Park, Mi-Rim, Kim, Nayeon, Jang, Gul Won, Park, Jong-Eun
Format: Article
Language:English
Subjects:
Age
Animals
Body weight
Body Weight - genetics
Chickens - genetics
Chromosome Mapping - veterinary
Gene loci
Gene regulation
Gene set enrichment analysis
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
MAP kinase
Meat
Motor activity
Polymorphism, Single Nucleotide
Poultry
Principal components analysis
Protein kinase
Quality control
Republic of Korea
Signal transduction
Single-nucleotide polymorphism
Software
Transcription
Ventilation
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Summary:Meat from Korean native chickens (KNCs) has high consumer demand; however, slow growth performance and high variation in body weight (BW) of KNCs remain an issue. Genome-wide association study (GWAS) is a powerful method to identify quantitative trait-associated genomic loci. A GWAS, based on a large-scale KNC population, is needed to identify underlying genetic mechanisms related to its growth traits. To identify BW-associated genomic regions, we performed a GWAS using the chicken 60K single nucleotide polymorphism (SNP) panel for 1328 KNCs. BW was measured at 8 weeks of age, from 2018 to 2020. Twelve SNPs were associated with BW at the suggestive significance level ( < 2.95 × 10 ) and located near or within 11 candidate genes, including , , , , and . Gene set enrichment analysis based on the GWAS results at < 0.05 (1680 SNPs) showed that 32 Gene Ontology terms and two Kyoto Encyclopedia of Genes and Genomes pathways, including regulation of transcription, motor activity, the mitogen-activated protein kinase signaling pathway, and tight junction, were significantly enriched ( < 0.05) for BW-associated genes. These pathways are involved in cell growth and development, related to BW gain. The identified SNPs are potential biomarkers in KNC breeding.
ISSN:2073-4425
2073-4425
DOI:10.3390/genes12081170