Troponin I Levels in Neonatal Hypoxic-Ischemic Encephalopathy Are Related to Cardiopulmonary Comorbidity and Neurodevelopmental Outcomes

Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic-Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional...

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Bibliographic Details
Published in:Journal of clinical medicine 2021-09, Vol.10 (17), p.4010
Main Authors: Lee, Inn-Chi, Yu, Chin-Sheng, Wong, Swee-Hee, Lue, Ko-Huang
Format: Article
Language:English
Subjects:
Biomarkers
Blood pressure
Brain damage
Clinical medicine
Comorbidity
Heart
Hypotension
Hypothermia
Hypoxia
Injuries
Ischemia
Lung diseases
Mortality
Newborn babies
Patients
Pediatrics
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Summary:Troponin I is a biomarker for cardiac injury in children. The role of troponin I in neonatal Hypoxic-Ischemic encephalopathy (HIE) may have valuable clinical implications. Troponin I levels were measured within 6 h of birth to determine their relationship to HIE stage, short-term cardiac functional outcomes, and neurodevelopmental outcomes at 1 year. Seventy-three patients were divided into two groups: mild HIE and moderate to severe HIE. Troponin I levels within 6 h of birth were obtained in 61 patients, and were significantly higher in patients with moderate to severe HIE than in patients with mild HIE (Mann-Whitney U test, U = 146, 0.001). A troponin I cut-off level of ≥60 pg/mL predicted moderate to severe HIE with a specificity of 81.1% and a negative prediction rate of 76.9%. A troponin I cut-off level of ≥180 pg/mL was significantly (χ (1, = 61) = 33.1, = 0.001, odds ratio 96.8) related with hypotension during first admission and significantly (χ (1, = 61) = 5.3, = 0.021, odds ratio 4.53) related with abnormal neurodevelopmental outcomes at 1 year. Early troponin I level may be a useful biomarker for predicting moderate to severe HIE, and initialization of hypothermia therapy.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10174010