SARS-CoV-2 new variants: Characteristic features and impact on the efficacy of different vaccines

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants reported in different countries have posed a serious threat to human health and social fabrics worldwide. In addition, these new variants hindered the efforts of vaccines and other therapeutic developm...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2021-11, Vol.143, p.112176-112176, Article 112176
Main Authors: Khan, Abbas, Khan, Taimoor, Ali, Shughla, Aftab, Summiya, Wang, Yanjing, Qiankun, Wang, Khan, Mazhar, Suleman, Muhammad, Ali, Shahid, Heng, Wang, Ali, Syed Shujait, Wei, Dong-Qing, Mohammad, Anwar
Format: Article
Language:English
Subjects:
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 - virology
COVID-19 Vaccines - classification
COVID-19 Vaccines - pharmacology
Humans
Immunogenicity, Vaccine
Infectivity
New Variants
Pathogenesis
SARS-CoV-2
SARS-CoV-2 - drug effects
SARS-CoV-2 - pathogenicity
SARS-CoV-2 - physiology
Therapeutics
Treatment Outcome
Vaccine
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its new variants reported in different countries have posed a serious threat to human health and social fabrics worldwide. In addition, these new variants hindered the efforts of vaccines and other therapeutic developments. In this review article, we explained the emergence of new variants of SARS-CoV-2, their transmission risk, mortality rate, and, more importantly, the impact of each new variant on the efficacy of the developed vaccines reported in different literature and findings. The literature reported that with the emergence of new variants, the efficacy of different vaccines is declined, hospitalization and the risk of reinfection is increased. The reports concluded that the emergence of a variant that entirely evades the immune response triggered by the vaccine is improbable. The emergence of new variants and reports of re-infections are creating a more distressing situation and therefore demands further investigation to formulate an effective therapeutic strategy.
ISSN:0753-3322
1950-6007
1950-6007
DOI:10.1016/j.biopha.2021.112176