Improved indocyanine green retention after short-term lenvatinib withdrawal in three patients with hepatocellular carcinoma

Use of lenvatinib, which has a high response rate in advanced hepatocellular carcinoma, sometimes results in tumor shrinkage and resectability of previously unresectable liver cancers. In Asia, including Japan, liver reserve, one of the determinants of resectability, is mainly determined by the indo...

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Bibliographic Details
Published in:Clinical journal of gastroenterology 2021-10, Vol.14 (5), p.1484-1490
Main Authors: Sugimoto, Rie, Inada, Hiroki, Tanaka, Yuki, Senju, Takeshi, Aratake, Yoshifusa, Nakanishi, Akira, Miki, Masami, Lee, Lingaku, Hisano, Terumasa, Matsumoto, Yoshihiro, Mano, Yohei, Iguchi, Tomohiro, Sugimachi, Keishi, Okumura, Yukihiko, Taguchi, Kenichi, Furukawa, Masayuki
Format: Article
Language:English
Subjects:
Abdominal Surgery
Carcinoma, Hepatocellular - drug therapy
Case Report
Colorectal Surgery
Gastroenterology
Hepatology
Humans
Indocyanine Green
Liver Neoplasms - drug therapy
Medicine
Medicine & Public Health
Phenylurea Compounds
Quinolines
Surgical Oncology
Vascular Endothelial Growth Factor A
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Summary:Use of lenvatinib, which has a high response rate in advanced hepatocellular carcinoma, sometimes results in tumor shrinkage and resectability of previously unresectable liver cancers. In Asia, including Japan, liver reserve, one of the determinants of resectability, is mainly determined by the indocyanine green (ICG) retention rate. Three patients with advanced liver cancer treated at our institution had very poor ICG retention rates during treatment with lenvatinib. Lenvatinib may reduce blood flow in both cancerous and non-cancerous regions by inhibiting vascular endothelial growth factor. Therefore, accurate determination of liver function likely requires withdrawal of this treatment several days before ICG retention testing.
ISSN:1865-7257
1865-7265
DOI:10.1007/s12328-021-01470-y