Ofloxacin Induced Hemolysis in G6PD-deficient Patient: A Rare Cause of Pigment Nephropathy

Thrombotic microangiopathy (TMA) commonly presents as a triad of acute kidney injury (AKI), jaundice, and hemolysis; however, tropical infections such as malaria, dengue, leptospira, and drugs like antimalarials can also have a similar presentation. They can cause AKI for many reasons including pre-...

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Bibliographic Details
Published in:Indian journal of nephrology 2021-07, Vol.31 (4), p.410-413
Main Authors: Parikh, Mital, Shah, Maulin, Hirapara, Jekishan, Soni, Shailesh, Vaishnav, Bhalendu, Ghosh, Labani
Format: Article
Language:English
Subjects:
Anemia
Antibiotics
Antimalarials
Case Report
Complications and side effects
Dextrose
Glucose
Hemolysis and hemolysins
Kidney diseases
Nephrology
Ofloxacin
Phosphates
Pigments
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Summary:Thrombotic microangiopathy (TMA) commonly presents as a triad of acute kidney injury (AKI), jaundice, and hemolysis; however, tropical infections such as malaria, dengue, leptospira, and drugs like antimalarials can also have a similar presentation. They can cause AKI for many reasons including pre-renal causes but an important yet not relatively uncommon genetic cause of hemolytic anemia, that is, glucose 6-phosphate deficiency (G6PD) manifesting as jaundice, hemolysis, and AKI secondary to pigment nephropathy after receiving offending drugs needs to be worked up while evaluating such patients. Ofloxacin is not usually included in the lists of unsafe drugs in G6PD deficiency. Herein, we report a patient developing intravascular hemolysis secondary to G6PD deficiency associated with ofloxacin administration presenting as a rare cause for pigment nephropathy.
ISSN:0971-4065
1998-3662
DOI:10.4103/ijn.IJN_138_20