Loading…

Cardiovascular Benefits of Phenol‐Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study

Scope The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol‐enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results VOHF assessed whether VOOs, enriche...

Full description

Saved in:
Bibliographic Details
Published in:Molecular nutrition & food research 2018-08, Vol.62 (16), p.e1800456-n/a
Main Authors: Pedret, Anna, Fernández‐Castillejo, Sara, Valls, Rosa‐Maria, Catalán, Úrsula, Rubió, Laura, Romeu, Marta, Macià, Alba, López de las Hazas, Maria Carmen, Farràs, Marta, Giralt, Montse, Mosele, Juana I., Martín‐Peláez, Sandra, Remaley, Alan T., Covas, Maria‐Isabel, Fitó, Montse, Motilva, Maria‐José, Solà, Rosa
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scope The main findings of the “Virgin Olive Oil and HDL Functionality” (VOHF) study and other related studies on the effect of phenol‐enriched virgin olive oil (VOO) supplementation on cardiovascular disease are integrated in the present work. Methods and results VOHF assessed whether VOOs, enriched with their own phenolic compounds (FVOO) or with those from thyme (FVOOT), improve quantity and functionality of HDL. In this randomized, double‐blind, crossover, and controlled trial, 33 hypercholesterolemic subjects received a control VOO (80 mg kg−1), FVOO (500 mg kg−1), and FVOOT (500 mg kg−1; 1:1) for 3 weeks. Both functional VOOs promoted cardioprotective changes, modulating HDL proteome, increasing fat‐soluble antioxidants, improving HDL subclasses distribution, reducing the lipoprotein insulin resistance index, increasing endogenous antioxidant enzymes, protecting DNA from oxidation, ameliorating endothelial function, and increasing fecal microbial metabolic activity. Additional cardioprotective benefits were observed according to phenol source and content in the phenol‐enriched VOOs. These insights support the beneficial effects of OO and PC from different sources. Conclusion Novel therapeutic strategies should increase HDL‐cholesterol levels and enhance HDL functionality. The tailoring of phenol‐enriched VOOs is an interesting and useful strategy for enhancing the functional quality of HDL, and thus, it can be used as a complementary tool for the management of hypercholesterolemic individuals. The VOHF project assesses whether virgin olive oils (VOO), enriched with their own phenols (FVOO) or with them plus phenols from thyme (FVOOT), improve the HDL functionality. Functional VOO enhances HDL functionality, modulating the glucose metabolism and increasing HDL cholesterol efflux capacity and its antioxidant, vasodilatory, and anti‐inflammatory properties through different mechanisms. These effects result in cardioprotective benefits.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.201800456