Management of biliary atresia: To transplant or not to transplant

• Published in: World journal of transplantation 2021-09, Vol.11 (9), p.400-409
• Main Authors: Kakos, Christos Dimitrios, Ziogas, Ioannis A, Alexopoulos, Sophoclis P, Tsoulfas, Georgios
• Format: Article
• Language: English
• Subjects: Minireviews
• ISSN: 2220-3230; 2220-3230
• DOI: 10.5500/wjt.v11.i9.400

Kasai procedure (KP) and liver transplantation (LT) represent the only therapeutic options for patients with biliary atresia (BA), the most common indication for LT in the pediatric population. However, KP represents by no means a radical option but rather a bridging one, as nearly all patients will finally require a liver graft. More and more experts in the field of transplant surgery propose that maybe it is time for a paradigm change in BA treatment and abandon KP as transplantation seems inevitable. Inadequacy of organs yet makes this option currently not feasible, so it seems useful to find ways to maximize the efficacy of KP. In previous decades, multiple studies tried to identify these factors which opt for better results, but in general, outcomes of KP have not improved to the level that was anticipated. This review provides the framework of conditions which favor native liver survival after KP and the ones which optimize a positive LT outcome. Strategies of transition of care at the right time are also presented, as transplantation plays a key role in the surgical treatment of BA. Future studies and further organization in the transplant field will allow for greater organ availability and better outcomes to be achieved for BA patients.