No Obvious Role for Suspicious Oral Pathogens in Arthritis Development

A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We asses...

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Bibliographic Details
Published in:International journal of environmental research and public health 2021-09, Vol.18 (18), p.9560
Main Authors: Rahajoe, Poerwati S., de Smit, Menke J., Raveling-Eelsing, Elisabeth, du Teil Espina, Marines, Stobernack, Tim, Lisotto, Paola, Harmsen, Hermie J. M., van Dijl, Jan Maarten, Kertia, Nyoman, Vissink, Arjan, Westra, Johanna
Format: Article
Language:English
Subjects:
Antibodies
Anticoagulants
Antigens
Arthritis
Autoantibodies
Bacterial infections
Breastfeeding & lactation
Cardiovascular disease
Diabetes
Gingiva
Gum disease
Hospitals
Hypertension
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Infections
Inflammation
Pathogens
Patients
Periodontitis
Postpartum period
Pregnancy
Proteins
Rheumatoid arthritis
Rheumatoid factor
Rheumatology
rRNA 16S
Serum levels
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Summary:A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies.
ISSN:1660-4601
1661-7827
1660-4601
DOI:10.3390/ijerph18189560