Utility of a Computerized ICD-10 Algorithm to Identify Idiosyncratic Drug-Induced Liver Injury Cases in the Electronic Medical Record

Introduction Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver injury that is difficult to diagnose and identify in the electronic medical record (EMR). Objective Our objective was to develop a computerized algorithm that can reliably identify DILI cases from the EMR. Met...

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Bibliographic Details
Published in:Drug safety 2020-04, Vol.43 (4), p.371-377
Main Authors: Yeboah-Korang, Amoah, Louissaint, Jeremy, Tsung, Irene, Prabhu, Sharmila, Fontana, Robert J.
Format: Article
Language:English
Subjects:
Acetaminophen
Algorithms
Analgesics
Antibiotics
Bile
Causality
Codes
Criminal investigations
Drug dosages
Drug Safety and Pharmacovigilance
Electronic health records
Electronic medical records
Hepatitis
Hepatotoxicity
Identification methods
Injuries
Laboratories
Liver
Medical records
Medicine
Medicine & Public Health
Natural language processing
Original Research Article
Patients
Pharmacology/Toxicology
Poisoning
Toxicity
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Summary:Introduction Idiosyncratic drug-induced liver injury (DILI) is an important cause of liver injury that is difficult to diagnose and identify in the electronic medical record (EMR). Objective Our objective was to develop a computerized algorithm that can reliably identify DILI cases from the EMR. Methods The EMR was searched for all encounters with an International Classification of Diseases, Tenth Revision (ICD-10) T code for drug toxicity and a K-71 code for toxic liver injury between 1 October 2015 and 30 September 2018. Clinically significant liver injury was defined using predetermined laboratory values. An expert opinion causality score (1–3 = probable DILI, 4/5 = non-DILI), Roussel Uclaf Causality Assessment Method (RUCAM) score, and severity score was assigned to each case. Results Among the 1,211,787 encounters searched, 517 had both an ICD-10 T code and a K-71 code, with 257 patients meeting the laboratory criteria. After excluding 75 cases of acetaminophen hepatotoxicity, the final study sample included 182 cases of potential DILI, with antineoplastics and antibiotics being the most frequently implicated agents. Causality assessment identified probable DILI in 121 patients (66.5%), whereas 61 (33.5%) had an alternative cause of liver injury. Although age, sex, race, and suspect drugs were similar, the probable DILI cases were more likely to present with a hepatocellular injury profile and have more severe liver injury than the non-DILI cases ( p  
ISSN:0114-5916
1179-1942
DOI:10.1007/s40264-019-00903-5