Men’s dietary patterns in relation to infertility treatment outcomes among couples undergoing in vitro fertilization

Purpose(s) To evaluate the relationship of men’s dietary patterns with outcomes of in vitro fertilization (IVF). Methods This is a prospective cohort study including 231 couples with 407 IVF cycles, presented at an academic fertility center from April 2007 to April 2018. We assessed diet with a vali...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2021-09, Vol.38 (9), p.2307-2318
Main Authors: Mitsunami, Makiko, Salas-Huetos, Albert, Mínguez-Alarcón, Lidia, Attaman, Jill A., Ford, Jennifer B., Kathrins, Martin, Souter, Irene, Chavarro, Jorge E.
Format: Article
Language:English
Subjects:
Adult
Assisted Reproduction Technologies
Couples
Diet
Embryo Implantation
Female
Fertility
Fertilization in Vitro - methods
Gynecology
Human Genetics
Humans
Implantation
In vitro fertilization
Infertility
Infertility - therapy
Live Birth - epidemiology
Male
Medicine
Medicine & Public Health
Pregnancy
Pregnancy Rate
Principal components analysis
Prospective Studies
Reproductive Medicine
Reproductive Techniques, Assisted
Sperm
Sperm Injections, Intracytoplasmic - methods
Treatment Outcome
United States - epidemiology
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Summary:Purpose(s) To evaluate the relationship of men’s dietary patterns with outcomes of in vitro fertilization (IVF). Methods This is a prospective cohort study including 231 couples with 407 IVF cycles, presented at an academic fertility center from April 2007 to April 2018. We assessed diet with a validated food frequency questionnaire and identified Dietary Pattern 1 and Dietary Pattern 2 using principal component analysis. We evaluated adjusted probability of IVF outcomes across the quartiles of the adherence to two dietary patterns by generalized linear mixed models. Results Men had a median age of 36.8 years and BMI of 26.9 kg/m 2 . Women’s median age and BMI were 35.0 years and 23.1 kg/m 2 , respectively. Adherence to Dietary Pattern 1 (r Pearson =0.44) and Dietary Pattern 2 (r Pearson =0.54) was positively correlated within couples. Adherence to Dietary Pattern 1 was positively associated with sperm concentration. A 1-unit increase in this pattern was associated with a 13.33 (0.71–25.96) million/mL higher sperm concentration. However, neither Dietary Pattern 1 nor Dietary Pattern 2 was associated with fertilization, implantation, clinical pregnancy, or live birth probabilities. Conclusions Data-derived dietary patterns were associated with semen quality but unrelated to the probability of successful IVF outcomes.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-021-02251-9