Insular cortex modulates social avoidance of sick rats

• Published in: Behavioural brain research 2022-01, Vol.416, p.113541-113541, Article 113541
• Main Authors: Rieger, Nathaniel S., Worley, Nicholas B., Ng, Alexandra J., Christianson, John P.
• Format: Article
• Language: English
• Subjects: Animals; Antiviral Agents - administration & dosage; Avoidance Learning - drug effects; Behavior, Animal - physiology; Female; GABA-A Receptor Agonists - pharmacology; Illness Behavior - drug effects; Insular cortex; Insular Cortex - drug effects; Male; Muscimol - pharmacology; Odorants; Poly I-C - administration & dosage; Rat; Rats; Sickness behavior; Social avoidance; Social Interaction; Social preference
• ISSN: 0166-4328; 1872-7549
• DOI: 10.1016/j.bbr.2021.113541

•Male and Female rats avoid sick adult but not sick juvenile conspecifics.•Insula cortex inactivation prevents avoidance of sick adults.•Insular cortex integrates sickness cues in order to make social decisions. Avoidance of sick individuals is vital to the preservation of one’s health and preventing transmission of communicable diseases. To do this successfully, one must identify social cues for sickness, which include sickness behaviors and chemosignals, and use this information to orchestrate social interactions. While many social species are highly capable with this process, the neural mechanisms that provide for social responses to sick individuals are only partially understood. To this end, we used a task in which experimental rats were allowed to investigate two conspecifics, one healthy and one sick. To imitate sickness, one conspecific received the viral mimic Polyinosinic:polycytidylic acid (Poly I:C) and the other saline. In a 5-minute social preference test, experimental male and female adult rats avoided Poly I:C treated adult conspecifics but did not adjust social interaction in response to Poly I:C treated juvenile conspecifics. Seeking a neural locus of this behavior, we inhibited the insular cortex, a region necessary for social behaviors directed toward conspecifics in distress. Insular cortex inactivation via administration of the GABAA agonist muscimol to experimental rats prior to social preference tests eliminated the preference to avoid sick adult conspecifics. These results suggest that some aspect of conspecific illness may be encoded in the insular cortex which is anatomically positioned to coordinate a situationally appropriate social response.