Effect of Prophylactic Dextrose Gel on Continuous Measures of Neonatal Glycemia: Secondary Analysis of the Pre-hPOD Trial

To determine the effects of different doses of prophylactic dextrose gel on glycemic stability assessed using continuous glucose monitoring in the first 48 hours when given to babies at risk of neonatal hypoglycemia. Continuous glucose monitoring was undertaken for the first 48 hours in 133 infants...

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Bibliographic Details
Published in:The Journal of pediatrics 2021-08, Vol.235, p.107-115.e4
Main Authors: Hegarty, Joanne E., Alsweiler, Jane M., Gamble, Gregory G., Crowther, Caroline A., Harding, Jane E.
Format: Article
Language:English
Subjects:
blood glucose
hyperglycemia
hypoglycemia
infant newborn
neonatal screening
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Summary:To determine the effects of different doses of prophylactic dextrose gel on glycemic stability assessed using continuous glucose monitoring in the first 48 hours when given to babies at risk of neonatal hypoglycemia. Continuous glucose monitoring was undertaken for the first 48 hours in 133 infants at risk of hypoglycemia who participated in the pre-hPOD randomized dosage trial of dextrose gel prophylaxis. Low glucose concentrations were detected in 41% of infants by blood glucose monitoring and 68% by continuous interstitial glucose monitoring. The mean ± SD duration of low interstitial glucose concentrations was 295 ± 351 minutes in the first 48 hours. Infants who received any dose of dextrose gel seemed to be less likely than those who received placebo gel to experience low glucose concentrations (
ISSN:0022-3476
1097-6833
DOI:10.1016/j.jpeds.2021.03.057