Thyroid Hormone Replacement Therapy Is Associated with Longer Overall Survival in Patients with Resectable Gastroesophageal Cancer: A Retrospective Single-Center Analysis

As thyroid hormones modulate proliferative pathways it is surmised that they can be associated with cancer development. Since the potential association of gastroesophageal cancer and thyroid disorders has not been addressed so far, the aim of this study was to investigate the association of thyroid...

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Bibliographic Details
Published in:Cancers 2021-10, Vol.13 (20), p.5050
Main Authors: Puhr, Hannah C, Reiter, Thorsten J, El-Mahrouk, Mohamed, Saliternig, Lena, Wolf, Peter, Mair, Maximilian J, Steindl, Ariane, Paireder, Matthias, Asari, Reza, Schoppmann, Sebastian F, Berghoff, Anna S, Preusser, Matthias, Ilhan-Mutlu, Aysegül
Format: Article
Language:English
Subjects:
Alcohol
Cancer therapies
Demographics
Gastric cancer
Histology
Hormone replacement therapy
Hospitals
Hyperthyroidism
Hypothyroidism
Localization
Medical diagnosis
Patients
Survival
Therapeutic applications
Thyroid cancer
Thyroid diseases
Thyroid gland
Thyroid hormones
Triiodothyronine
Tumors
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Summary:As thyroid hormones modulate proliferative pathways it is surmised that they can be associated with cancer development. Since the potential association of gastroesophageal cancer and thyroid disorders has not been addressed so far, the aim of this study was to investigate the association of thyroid hormone parameters with the outcome of these patients, so novel prognostic and even potentially therapeutic markers can be defined. Clinical and endocrinological parameters of patients with resectable gastroesophageal cancer treated between 1990 and 2018 at the Vienna General Hospital, Austria, including history of endocrinological disorders and laboratory analyses of thyroid hormones at first cancer diagnosis were investigated and correlated with the overall survival (OS). In a total of 865 patients, a tendency towards prolonged OS in hypothyroid patients (euthyroid, = 647: median OS 29.7 months; hyperthyroid, = 50: 23.1 months; hypothyroid, = 70: 47.9 months; = 0.069) as well as a significant positive correlation of thyroid hormone replacement therapy with the OS was observed (without, = 53: median OS 30.6 months; with, = 67: 51.3 months; = 0.017). Furthermore, triiodothyronine (T3) levels were also associated with the OS (median OS within the limit of normal: 23.4, above: 32.4, below: 9.6 months; = 0.045). Thyroid disorders and their therapeutic interventions might be associated with the OS in patients with resectable gastroesophageal cancer. As data on the correlation of these parameters is scarce, this study proposes an important impulse for further analyses concerning the association of thyroid hormones with the outcome in patients with gastroesophageal tumors.
ISSN:2072-6694
2072-6694
DOI:10.3390/cancers13205050