Signal properties of split-spectrum amplitude decorrelation angiography for quantitative optical coherence tomography-based velocimetry

Split-spectrum amplitude-decorrelation angiography (SSADA) is a noninvasive and three-dimensional angiographic technique with a microscale spatial resolution based on optical coherence tomography. The SSADA signal is known to be correlated with the blood flow velocity and the quantitative velocimetr...

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Bibliographic Details
Published in:Biomedical optics express 2021-10, Vol.12 (10), p.5955-5968
Main Authors: Nakamichi, Yu, Chiu, Kai-shih, Sun, Chia-Wei
Format: Article
Language:English
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Summary:Split-spectrum amplitude-decorrelation angiography (SSADA) is a noninvasive and three-dimensional angiographic technique with a microscale spatial resolution based on optical coherence tomography. The SSADA signal is known to be correlated with the blood flow velocity and the quantitative velocimetry with SSADA has been expected; however, the signal properties of SSADA are not completely understood due to lack of comprehensive investigations of parameters related to SSADA signals. In this study, phantom experiments were performed to comprehensively investigate the relation of SSADA signals with flow velocities, time separations, particle concentrations, signal-to-noise ratios, beam spot sizes, and viscosities, and revealed that SSADA signals reflect the spatial commonality within a coherence volume between adjacent A-scans.
ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.432297