Real-time linear prediction of simultaneous and independent movements of two finger groups using an intracortical brain-machine interface

• Published in: Neuron (Cambridge, Mass.) Mass.), 2021-10, Vol.109 (19), p.3164-3177.e8
• Main Authors: Nason, Samuel R., Mender, Matthew J., Vaskov, Alex K., Willsey, Matthew S., Ganesh Kumar, Nishant, Kung, Theodore A., Patil, Parag G., Chestek, Cynthia A.
• Format: Article
• Language: English
• Subjects: brain-machine interface; hand prosthesis; intracortical; linear decoder; multiple simultaneous targets; primary motor cortex
• ISSN: 0896-6273; 1097-4199
• DOI: 10.1016/j.neuron.2021.08.009

Modern brain-machine interfaces can return function to people with paralysis, but current upper extremity brain-machine interfaces are unable to reproduce control of individuated finger movements. Here, for the first time, we present a real-time, high-speed, linear brain-machine interface in nonhuman primates that utilizes intracortical neural signals to bridge this gap. We created a non-prehensile task that systematically individuates two finger groups, the index finger and the middle-ring-small fingers combined. During online brain control, the ReFIT Kalman filter could predict individuated finger group movements with high performance. Next, training ridge regression decoders with individual movements was sufficient to predict untrained combined movements and vice versa. Finally, we compared the postural and movement tuning of finger-related cortical activity to find that individual cortical units simultaneously encode multiple behavioral dimensions. Our results suggest that linear decoders may be sufficient for brain-machine interfaces to execute high-dimensional tasks with the performance levels required for naturalistic neural prostheses. [Display omitted] •Simultaneous and independent brain-machine interface control of two finger groups•Cortical tuning between manipulandum and brain-machine interface use is consistent•Linear decoders can predict untrained finger movements•Cortical units simultaneously encode multiple kinematic dimensions Nason et al. present a real-time brain-machine interface for controlling the simultaneous and independent movements of two groups of fingers in nonhuman primates. These techniques can be used to restore naturalistic control of paralyzed hands and enable a deeper understanding of how motor cortex represents dexterous finger behaviors.