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Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?
Purpose Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced chang...
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| Published in: | Sport sciences for health 2021-09, Vol.17 (3), p.753-762 |
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| container_issue | 3 |
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| container_title | Sport sciences for health |
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| creator | Carter, Sophie E. Draijer, Richard Stewart, Claire E. Moss, Andy D. Thijssen, Dick H. J. Hopkins, Nicola D. |
| description | Purpose
Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition.
Methods
Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m
−2
) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses.
Results
Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (
p
0.05).
Conclusion
Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances. |
| doi_str_mv | 10.1007/s11332-021-00753-8 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8550027</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2591229703</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-8936c00592e2da7d1eda06734aa4f691e031003bdc26a4f068933a3275c318e43</originalsourceid><addsrcrecordid>eNp9UUtrFTEUHkSxD_0DLmTATTfRPCeTjVJKq0LBTbsO52bO3KbMJNckc8F_b3qn1sdCCOQk3yPn5GuaN4y-Z5TqD5kxITihnJF6VIL0z5pj1nNFGBfy-aGWREtDj5qTnO8pVZ1S5mVzJKTmrDPdcbM_T9iCWwq22Zfiw5b4MCwOh9bdQdhibn2oa5xgnqH4GFoIFcOEmxT3kN0yQWrHJbgDmHCCUsUltn7egU-1nmMcVlXcBv9A-_SqeTHClPH1437a3F5d3lx8IdffPn-9OL8mTmpZSG9E52rbhiMfQA8MB6CdFhJAjp1hSEX9CbEZHO_qDe2qQIDgWjnBepTitPm4-u6WzYyDw1ASTHaX_Azph43g7d9I8Hd2G_e2V4pSrqvB2aNBit8XzMXOPjucJggYl2y5Moxzo6mo1Hf_UO_jkkIdz3LDemm4FKqy-MpyKeaccHxqhlH7EKtdY7U1VnuI1fZV9PbPMZ4kv3KsBLEScoVqaun32_-x_QlSaq9A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2918492435</pqid></control><display><type>article</type><title>Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?</title><source>Springer Link</source><creator>Carter, Sophie E. ; Draijer, Richard ; Stewart, Claire E. ; Moss, Andy D. ; Thijssen, Dick H. J. ; Hopkins, Nicola D.</creator><creatorcontrib>Carter, Sophie E. ; Draijer, Richard ; Stewart, Claire E. ; Moss, Andy D. ; Thijssen, Dick H. J. ; Hopkins, Nicola D.</creatorcontrib><description>Purpose
Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition.
Methods
Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m
−2
) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses.
Results
Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (
p
< 0.05), MCAv reduced (∆-2.9 cm∙s
−1
,
p
= 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg
−1
,
p
= 0.016). Positive affect (∆-4.6,
p
< 0.001), and alert (∆-10.6
p
= 0.002) and contented (∆-7.4,
p
= 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (
p
> 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (
p
> 0.05).
Conclusion
Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.</description><identifier>ISSN: 1824-7490</identifier><identifier>EISSN: 1825-1234</identifier><identifier>DOI: 10.1007/s11332-021-00753-8</identifier><identifier>PMID: 34721696</identifier><language>eng</language><publisher>Milan: Springer Milan</publisher><subject>Bats ; Carbon dioxide ; Cognition & reasoning ; Human Physiology ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Original ; Original Article ; Sports Medicine ; Tumor necrosis factor-TNF</subject><ispartof>Sport sciences for health, 2021-09, Vol.17 (3), p.753-762</ispartof><rights>The Author(s) 2021</rights><rights>The Author(s) 2021.</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-8936c00592e2da7d1eda06734aa4f691e031003bdc26a4f068933a3275c318e43</citedby><cites>FETCH-LOGICAL-c474t-8936c00592e2da7d1eda06734aa4f691e031003bdc26a4f068933a3275c318e43</cites><orcidid>0000-0003-2815-7360</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34721696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carter, Sophie E.</creatorcontrib><creatorcontrib>Draijer, Richard</creatorcontrib><creatorcontrib>Stewart, Claire E.</creatorcontrib><creatorcontrib>Moss, Andy D.</creatorcontrib><creatorcontrib>Thijssen, Dick H. J.</creatorcontrib><creatorcontrib>Hopkins, Nicola D.</creatorcontrib><title>Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?</title><title>Sport sciences for health</title><addtitle>Sport Sci Health</addtitle><addtitle>Sport Sci Health</addtitle><description>Purpose
Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition.
Methods
Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m
−2
) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses.
Results
Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (
p
< 0.05), MCAv reduced (∆-2.9 cm∙s
−1
,
p
= 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg
−1
,
p
= 0.016). Positive affect (∆-4.6,
p
< 0.001), and alert (∆-10.6
p
= 0.002) and contented (∆-7.4,
p
= 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (
p
> 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (
p
> 0.05).
Conclusion
Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.</description><subject>Bats</subject><subject>Carbon dioxide</subject><subject>Cognition & reasoning</subject><subject>Human Physiology</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Original</subject><subject>Original Article</subject><subject>Sports Medicine</subject><subject>Tumor necrosis factor-TNF</subject><issn>1824-7490</issn><issn>1825-1234</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9UUtrFTEUHkSxD_0DLmTATTfRPCeTjVJKq0LBTbsO52bO3KbMJNckc8F_b3qn1sdCCOQk3yPn5GuaN4y-Z5TqD5kxITihnJF6VIL0z5pj1nNFGBfy-aGWREtDj5qTnO8pVZ1S5mVzJKTmrDPdcbM_T9iCWwq22Zfiw5b4MCwOh9bdQdhibn2oa5xgnqH4GFoIFcOEmxT3kN0yQWrHJbgDmHCCUsUltn7egU-1nmMcVlXcBv9A-_SqeTHClPH1437a3F5d3lx8IdffPn-9OL8mTmpZSG9E52rbhiMfQA8MB6CdFhJAjp1hSEX9CbEZHO_qDe2qQIDgWjnBepTitPm4-u6WzYyDw1ASTHaX_Azph43g7d9I8Hd2G_e2V4pSrqvB2aNBit8XzMXOPjucJggYl2y5Moxzo6mo1Hf_UO_jkkIdz3LDemm4FKqy-MpyKeaccHxqhlH7EKtdY7U1VnuI1fZV9PbPMZ4kv3KsBLEScoVqaun32_-x_QlSaq9A</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Carter, Sophie E.</creator><creator>Draijer, Richard</creator><creator>Stewart, Claire E.</creator><creator>Moss, Andy D.</creator><creator>Thijssen, Dick H. J.</creator><creator>Hopkins, Nicola D.</creator><general>Springer Milan</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-2815-7360</orcidid></search><sort><creationdate>20210901</creationdate><title>Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?</title><author>Carter, Sophie E. ; Draijer, Richard ; Stewart, Claire E. ; Moss, Andy D. ; Thijssen, Dick H. J. ; Hopkins, Nicola D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-8936c00592e2da7d1eda06734aa4f691e031003bdc26a4f068933a3275c318e43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bats</topic><topic>Carbon dioxide</topic><topic>Cognition & reasoning</topic><topic>Human Physiology</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Original</topic><topic>Original Article</topic><topic>Sports Medicine</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carter, Sophie E.</creatorcontrib><creatorcontrib>Draijer, Richard</creatorcontrib><creatorcontrib>Stewart, Claire E.</creatorcontrib><creatorcontrib>Moss, Andy D.</creatorcontrib><creatorcontrib>Thijssen, Dick H. J.</creatorcontrib><creatorcontrib>Hopkins, Nicola D.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sport sciences for health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carter, Sophie E.</au><au>Draijer, Richard</au><au>Stewart, Claire E.</au><au>Moss, Andy D.</au><au>Thijssen, Dick H. J.</au><au>Hopkins, Nicola D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition?</atitle><jtitle>Sport sciences for health</jtitle><stitle>Sport Sci Health</stitle><addtitle>Sport Sci Health</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>17</volume><issue>3</issue><spage>753</spage><epage>762</epage><pages>753-762</pages><issn>1824-7490</issn><eissn>1825-1234</eissn><abstract>Purpose
Sedentary behaviour is negatively associated with mood and cognition, yet how acute sitting contributes to these overall associations is unknown. Since sitting heightens inflammation and impairs cerebrovascular function, this study investigated the hypothesis that these sitting-induced changes are related to impaired mood and cognition.
Methods
Twenty-five healthy desk workers (18 male, 28.3 ± 7.5 years, BMI: 24.2 ± 3.3 kg∙m
−2
) were recruited. During laboratory visit one, participants were familiarised with cognitive performance tests measuring executive function, attention and working memory. During laboratory visit two, participants completed 6 h of continuous, uninterrupted sitting. At baseline and after 6 h, serum markers of inflammation, middle cerebral artery blood flow velocity (MCAv), cerebrovascular carbon dioxide reactivity (CVR), dynamic cerebral autoregulation (CA), cognitive performance and mood (positive and negative affect, alert, contented and calm) were assessed. Data were analysed using paired-samples t tests and correlation analyses.
Results
Following sitting, C-reactive protein (∆-1.0 µg/ml) and tissue plasminogen activator (∆-360.4 pg/ml) decreased (
p
< 0.05), MCAv reduced (∆-2.9 cm∙s
−1
,
p
= 0.012) and normalised gain increased in the very low frequency range, indicating impaired CA (∆ + 0.22%·mmHg
−1
,
p
= 0.016). Positive affect (∆-4.6,
p
< 0.001), and alert (∆-10.6
p
= 0.002) and contented (∆-7.4,
p
= 0.006) mood states also decreased following sitting. No significant changes in interleukin-6, tumour necrosis factor-alpha, von Willebrand factor, CVR or cognitive performance were observed (
p
> 0.05). The observed changes in inflammation and cerebrovascular function were not related to changes in mood (
p
> 0.05).
Conclusion
Alterations in inflammation or cerebrovascular function following six hours of prolonged, uninterrupted sitting are not related to the observed reductions in mood, indicating other mechanisms underlie the relationship between acute sitting and mood disturbances.</abstract><cop>Milan</cop><pub>Springer Milan</pub><pmid>34721696</pmid><doi>10.1007/s11332-021-00753-8</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-2815-7360</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Sport sciences for health, 2021-09, Vol.17 (3), p.753-762 |
| issn | 1824-7490 1825-1234 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8550027 |
| source | Springer Link |
| subjects | Bats Carbon dioxide Cognition & reasoning Human Physiology Medicine Medicine & Public Health Metabolic Diseases Original Original Article Sports Medicine Tumor necrosis factor-TNF |
| title | Are acute sitting-induced changes in inflammation and cerebrovascular function related to impaired mood and cognition? |
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