Pericardial and myocardial involvement after SARS-CoV-2 infection: a cross-sectional descriptive study in healthcare workers

The cardiac sequelae of SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in healthcare workers to report evidence of pericardial and myocardial involvement after SARS-CoV-2 infection. We studied 139 healthcare workers with confirmed past SARS-CoV-2 infection. Pa...

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Bibliographic Details
Published in:Revista española de cardiología (English ed.) 2022-09, Vol.75 (9), p.734-746
Main Authors: Eiros, Rocío, Barreiro-Pérez, Manuel, Martín-García, Ana, Almeida, Julia, Villacorta, Eduardo, Pérez-Pons, Alba, Merchán, Soraya, Torres-Valle, Alba, Sánchez-Pablo, Clara, González-Calle, David, Pérez-Escurza, Oihane, Toranzo, Inés, Díaz-Peláez, Elena, Fuentes-Herrero, Blanca, Macías-Álvarez, Laura, Oliva-Ariza, Guillermo, Lecrevisse, Quentin, Fluxa, Rafael, Bravo-Grande, José L., Orfao, Alberto, Sánchez, Pedro L.
Format: Article
Language:English
Subjects:
Arrhythmias, Cardiac - complications
Cardiac injury
Cardiac magnetic resonance
COVID-19
COVID-19 - complications
COVID-19 - epidemiology
Cross-Sectional Studies
Células inmunes
Daño cardiaco
Female
Health Personnel
Healthcare worker
Humans
Immune cells
Immune response
Male
Middle Aged
Miocarditis
Myocarditis
Myocarditis - diagnosis
Myocarditis - epidemiology
Myocarditis - etiology
Original
Pericarditis
Pericarditis - diagnosis
Pericarditis - epidemiology
Pericarditis - etiology
Resonancia magnética cardiaca
Respuesta inmune
SARS-CoV-2
Serology
Serología
Trabajador sanitario
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Summary:The cardiac sequelae of SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in healthcare workers to report evidence of pericardial and myocardial involvement after SARS-CoV-2 infection. We studied 139 healthcare workers with confirmed past SARS-CoV-2 infection. Participants underwent clinical assessment, electrocardiography, and laboratory tests, including immune cell profiling and cardiac magnetic resonance (CMR). Clinically suspected pericarditis was diagnosed when classic criteria were present and clinically suspected myocarditis was based on the combination of at least 2 CMR criteria. Median age was 52 (41-57) years, 71.9% were women, and 16.5% were previously hospitalized for COVID-19 pneumonia. On examination (10.4 [9.3-11.0] weeks after infection-like symptoms), participants showed hemodynamic stability. Chest pain, dyspnea or palpitations were present in 41.7% participants, electrocardiographic abnormalities in 49.6%, NT-proBNP elevation in 7.9%, troponin in 0.7%, and CMR abnormalities in 60.4%. A total of 30.9% participants met criteria for either pericarditis and/or myocarditis: isolated pericarditis was diagnosed in 5.8%, myopericarditis in 7.9%, and isolated myocarditis in 17.3%. Most participants (73.2%) showed altered immune cell counts in blood, particularly decreased eosinophil (27.3%; P
ISSN:1885-5857
1885-5857
DOI:10.1016/j.rec.2021.11.001