Antioxidant supplementations ameliorate PCOS complications: a review of RCTs and insights into the underlying mechanisms

Polycystic ovary syndrome (PCOS) is one of the most important gynecological disorders of women in the age of reproduction. Different hormonal and inflammatory cross-talks may play in the appearance of its eventual complications as a leading cause of infertility. Excessive production of reactive oxyg...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2021-11, Vol.38 (11), p.2817-2831
Main Authors: Gharaei, Roghaye, Mahdavinezhad, Forough, Samadian, Esmaeil, Asadi, Jahanbakhsh, Ashrafnezhad, Zhaleh, Kashani, Ladan, Amidi, Fardin
Format: Article
Language:English
Subjects:
Antioxidants
Antioxidants - pharmacology
Clinical trials
Clinical Trials as Topic
Dietary Supplements
Female
Gynecology
Human Genetics
Humans
Infertility
Inflammation
Medicine
Medicine & Public Health
Oxidative stress
Oxidative Stress - drug effects
Polycystic ovary syndrome
Polycystic Ovary Syndrome - drug therapy
Polycystic Ovary Syndrome - metabolism
Reactive oxygen species
Reactive Oxygen Species - metabolism
Reproductive Medicine
Review
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Summary:Polycystic ovary syndrome (PCOS) is one of the most important gynecological disorders of women in the age of reproduction. Different hormonal and inflammatory cross-talks may play in the appearance of its eventual complications as a leading cause of infertility. Excessive production of reactive oxygen species over the power of the antioxidant system as oxidative stress is known to contribute to a variety of diseases like PCOS. Thus, the utilization of antioxidants can be efficient in preventing or assistant in treating these diseases. In this review, we describe the clinical trial studies that have examined the efficiency of antioxidant strategies against PCOS and the possible underlying mechanisms. The investigations presented here lead us to consider that targeting oxidative stress pathways is probably a powerful promising therapeutic approach towards PCOS. There is preparatory evidence of the effectiveness of antioxidant interventions in ameliorating some of the PCOS complications, including metabolic and hormonal disorders. Due to limited data and relatively few clinical trials, many of these interventions need further investigation before they can be considered effective agents for routine clinical use.
ISSN:1058-0468
1573-7330
DOI:10.1007/s10815-021-02342-7