Dilithium Amides as a Modular Bis-Anionic Ligand Platform for Iron-Catalyzed Cross-Coupling

Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada–Tamao–Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized ele...

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Bibliographic Details
Published in:Organic letters 2021-08, Vol.23 (15), p.5958-5963
Main Authors: Neate, Peter G. N, Zhang, Bufan, Conforti, Jessica, Brennessel, William W, Neidig, Michael L
Format: Article
Language:English
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Summary:Dilithium amides have been developed as a bespoke and general ligand for iron-catalyzed Kumada–Tamao–Corriu cross-coupling reactions, their design taking inspiration from previous mechanistic and structural studies. They allow for the cross-coupling of alkyl Grignard reagents with sp2-hybridized electrophiles as well as aryl Grignard reagents with sp3-hybridized electrophiles. This represents a rare example of a single iron-catalyzed system effective across diverse coupling reactions without significant modification of the catalytic protocol, as well as remaining operationally simple.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.1c02053