Antibody responses to the SARS‐CoV‐2 vaccines in hemodialysis patients: Is inactivated vaccine effective?

Introduction Vaccines generally have reduced effectiveness in hemodialysis patients and a similar condition may also apply for the SARS‐CoV‐2 vaccines. The aim of this study was to analyze humoral responses of hemodialysis patients to SARS‐CoV‐2 vaccines. Methods Eighty‐five maintenance hemodialysis...

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Bibliographic Details
Published in:Therapeutic apheresis and dialysis 2022-08, Vol.26 (4), p.769-774
Main Authors: Murt, Ahmet, Altiparmak, Mehmet Rıza, Yadigar, Serap, Yalin, Serkan Feyyaz, Ozbey, Dogukan, Yildiz, Zeynep, Kocazeybek, Bekir, Pekpak, Meltem, Ataman, Muveddet Rezzan
Format: Article
Language:English
Subjects:
Antibodies, Viral
Antibody Formation
COVID-19 - prevention & control
COVID-19 Vaccines
COVID‐19
hemodialysis
Humans
immunization
Immunoglobulin G
mRNA Vaccines
Original
Renal Dialysis
SARS-CoV-2
Spike Glycoprotein, Coronavirus
vaccine
Vaccines, Inactivated
Vaccines, Synthetic
Viral Vaccines
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Summary:Introduction Vaccines generally have reduced effectiveness in hemodialysis patients and a similar condition may also apply for the SARS‐CoV‐2 vaccines. The aim of this study was to analyze humoral responses of hemodialysis patients to SARS‐CoV‐2 vaccines. Methods Eighty‐five maintenance hemodialysis patients who received either inactivated or mRNA SARS‐CoV‐2 vaccines were investigated. Antibody levels were measured by a commercial antibody kit, which detected antibodies toward receptor binding domain of the SARS‐CoV‐2 spike protein. Comparative analyzes were carried between vaccine groups and with a control group of 103 healthy volunteers. Results Seropositivity rate and antibody levels were significantly lower in hemodialysis patients who received inactivated vaccine (p = 0.000). While mRNA vaccine had better immunogenicity, both vaccines protected from symptomatic infection when seropositivity was achieved. Discussion/Conclusion When used in the same dose with the general population, inactivated SARS‐CoV‐2 vaccines generate reduced humoral response in hemodialysis patients. mRNA vaccines have better immunogenicity in this group.
ISSN:1744-9979
1744-9987
DOI:10.1111/1744-9987.13752