SARS‐CoV‐2 as a mimicker of pulmonary metastasis in osteosarcoma

The most commonly reported CT finding is a single or multiple pleural-based nodules with lung parenchymal metastasis.1 Despite multimodal therapy with chemotherapy and surgical resection, recurrence still occurs in approximately 30%–40% of patients with 80% of relapse to the lungs.2 In a single-cent...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric Blood & Cancer 2022-06, Vol.69 (6), p.e29435-n/a
Main Authors: Offenbacher, Rachel, Fabish, Lara, Baker, Alissa, Loeb, David M.
Format: Article
Language:English
Subjects:
Bone cancer
Bone Neoplasms - diagnostic imaging
Bone Neoplasms - pathology
COVID-19
Hematology
Humans
Letter to the Editor
Letters to the Editor
Lung cancer
Lung Neoplasms - secondary
Metastases
Neoplasm Metastasis
Oncology
Osteosarcoma
Osteosarcoma - pathology
Pediatrics
Sarcoma
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Citations: Items that this one cites
Items that cite this one
Online Access:Request full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The most commonly reported CT finding is a single or multiple pleural-based nodules with lung parenchymal metastasis.1 Despite multimodal therapy with chemotherapy and surgical resection, recurrence still occurs in approximately 30%–40% of patients with 80% of relapse to the lungs.2 In a single-center study, the overall incidence of developing pulmonary metastasis at 5 years was 28% irrespective of age.3 COVID-19, a highly infectious disease caused by the SARS-CoV-2 virus, was declared a global pandemic in January 2020. Ground glass opacities are described as the most common imaging finding with occurrences as high as 98%.6 Other findings appreciated include reticular pattern, air bronchogram, airway and pleura changes, pulmonary edema or fibrosis, and vascular enlargement.7 Nodules measuring less than 3 cm in diameter are an atypical, but described, phenomenon in the setting of viral pneumonia in adults.7 Contrary to adults, pediatric patients with COVID-19 do not always present with respiratory symptomatology. Symptoms are typically milder among children and findings were not often evident on chest X-rays.8 In a study evaluating chest CT scans of pediatric patients with confirmed COVID-19, typical manifestations included unilateral or bilateral subpleural ground-glass opacities, and consolidations with surrounding halo sign.8 Additionally, the lesions on chest CT lagged behind clinical symptoms and remained present even after two consecutive negative RT-PCR tests.8 As oncologists, when we see a new lesion on screening imaging, we are tasked with careful evaluation.
ISSN:1545-5009
1545-5017
DOI:10.1002/pbc.29435