Vicinal halo-trifluoromethylation of alkenes

Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry. Due to their prevalence and easy accessibility, alkene halo-trifluoromethylation p...

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Published in:RSC advances 2021-04, Vol.11 (25), p.14941-14955
Main Authors: Kareem, Rzgar Tawfeeq, Azizi, Bayan, Asnaashariisfahani, Manzarbanou, Ebadi, Abdolghaffar, Vessally, Esmail
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Language:English
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Alkenes
Chemistry
Organic chemistry
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creator Kareem, Rzgar Tawfeeq
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description Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry. Due to their prevalence and easy accessibility, alkene halo-trifluoromethylation provides a convenient way to install these valuable functionalities in complex targets. In this review, we summarize recent advances and achievements in this fast-growing research field. For clarity, the reactions were classified according to the type of halogen atom. Both trifluoromethyl and halide groups are widely found in medicinally and pharmaceutically important compounds and, moreover, organohalides are commonly used as versatile intermediates in synthetic organic chemistry.
doi_str_mv 10.1039/d0ra06872a
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subjects Alkenes
Chemistry
Organic chemistry
title Vicinal halo-trifluoromethylation of alkenes
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