Assessment of Sleep among Patients with Chronic Liver Disease: Association with Quality of Life

The present study aims to assess the sleep characteristics and health-related quality of life (HRQOL) among patients with chronic liver diseases (CLDs), as well as the relationship between them. We conducted a prospective cross-sectional study, over a period of eight months, on patients with CLDs. S...

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Bibliographic Details
Published in:Journal of personalized medicine 2021-12, Vol.11 (12), p.1387
Main Authors: Plotogea, Oana-Mihaela, Gheorghe, Gina, Stan-Ilie, Madalina, Constantinescu, Gabriel, Bacalbasa, Nicolae, Bungau, Simona, Diaconu, Camelia Cristina
Format: Article
Language:English
Subjects:
Cardiovascular disease
Chronic illnesses
Cirrhosis
Diabetes
Etiology
Hepatitis
Liver cirrhosis
Liver diseases
Mental health
Precision medicine
Quality of life
Questionnaires
Sleep
Sleep and wakefulness
Software
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Summary:The present study aims to assess the sleep characteristics and health-related quality of life (HRQOL) among patients with chronic liver diseases (CLDs), as well as the relationship between them. We conducted a prospective cross-sectional study, over a period of eight months, on patients with CLDs. Sleep was assessed by subjective tools (self-reported validated questionnaires), semi-objective methods (actigraphy), and HRQOL by using the 36-Item Short Form Survey (SF-36) and Chronic Liver Disease Questionnaire (CLDQ). The results indicated that 48.21% of patients with CLDs had a mean Pittsburgh Sleep Quality Index (PSQI) score higher than five, suggestive of poor sleep; 39.29% of patients had a mean Epworth Sleepiness Scale (ESS) score ≥11, indicative of daytime sleepiness. Actigraphy monitoring showed that patients with cirrhosis had significantly more delayed bedtime hours and get-up hours, more awakenings, and more reduced sleep efficacy when compared to pre-cirrhotics. The CLDQ and SF-36 questionnaire scores were significantly lower in cirrhotics compared to pre-cirrhotics within each domain. Moreover, we identified significant correlations between the variables from each questionnaire, referring to HRQOL and sleep parameters. In conclusion, sleep disturbances are commonly encountered among patients with CLDs and are associated with impaired HRQOL. This is the first study in Romania that assesses sleep by actigraphy in a cohort of patients with different stages of CLD.
ISSN:2075-4426
2075-4426
DOI:10.3390/jpm11121387