A randomized controlled trial of a structured program combining aerobic and resistance exercise for adults with type 2 diabetes in Japan

• Published in: Diabetology international 2022-01, Vol.13 (1), p.75-84
• Main Authors: Terauchi, Yasuo, Takada, Tetsushi, Yoshida, Satoshi
• Format: Article
• Language: English
• Subjects: Blood glucose; Diabetes; Diabetes mellitus (non-insulin dependent); Endocrinology; Exercise; Fasting; Glucose; Hemoglobin; Insulin; Insulin resistance; Medicine; Medicine & Public Health; Metabolic Diseases; Original; Original Article; Patients; Physical fitness
• ISSN: 2190-1678; 2190-1686
• DOI: 10.1007/s13340-021-00506-5

Background We assessed the effect of supervised, combined aerobic and resistance exercise on diabetic parameters in Japanese patients with type 2 diabetes mellitus (T2DM). Methods This 12-week, multicenter (17 medical institutions), open-label, parallel-group study (clinicaltrials.jp; JapicCTI-184002), randomized (1:1) Japanese patients aged 20–75 years with T2DM and hemoglobin A1c (HbA1c) of 7.0–10.0% to supervised exercise ( n  = 113) or standard therapy ( n  = 115). The supervised exercise group undertook supervised aerobic (30 min) and resistance exercise 3 times/week (20 designated gyms). Primary endpoint was change in HbA1c from baseline at week 13. Secondary endpoints were change in fasting blood glucose (FBG), glycoalbumin, fasting insulin, homeostatic model assessment of insulin resistance (HOMA-IR), and HOMA-β at week 13. Results Of 228 randomized patients, 97 (85.8%) in the supervised exercise group and 108 (93.9%) in the standard therapy group completed the study. Supervised exercise significantly lowered HbA1c at week 13 versus standard therapy (estimated difference in change from baseline [95% confidence interval]: − 0.44% [− 0.61, − 0.28], p