Long-Term Outcomes and Prognostic Factors in Kidney Transplant Recipients with Polycystic Kidney Disease

Polycystic kidney disease (PKD) accounts for approximately 15% of kidney transplants, but long-term outcomes in patients with PKD who have received a kidney transplant are not well understood. In primary recipients of kidney transplants at our center (1994-2014), we compared outcomes of underlying P...

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Bibliographic Details
Published in:Kidney360 2021-02, Vol.2 (2), p.312-324
Main Authors: Bhutani, Gauri, Astor, Brad C, Mandelbrot, Didier A, Mankowski-Gettle, Lori, Ziemlewicz, Timothy, Wells, Shane A, Frater-Rubsam, Leah, Horner, Vanessa, Boyer, Courtney, Laffin, Jennifer, Djamali, Arjang
Format: Article
Language:English
Subjects:
Graft Survival
Humans
Kidney Transplantation - adverse effects
Original Investigations
Polycystic Kidney Diseases - surgery
Prognosis
Prospective Studies
Renal Dialysis
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Summary:Polycystic kidney disease (PKD) accounts for approximately 15% of kidney transplants, but long-term outcomes in patients with PKD who have received a kidney transplant are not well understood. In primary recipients of kidney transplants at our center (1994-2014), we compared outcomes of underlying PKD ( =619) with other native diseases (non-PKD, =4312). Potential factors influencing outcomes in PKD were evaluated using Cox proportional-hazards regression and a rigorous multivariable model. Patients with PKD were older and were less likely to be sensitized or to experience delayed graft function (DGF). Over a median follow-up of 5.6 years, 1256 of all recipients experienced death-censored graft failure (DCGF; 115 patients with PKD) and 1617 died (154 patients with PKD). After adjustment for demographic, dialysis, comorbid disease, surgical, and immunologic variables, patients with PKD had a lower risk of DCGF (adjusted hazard ratio [aHR], 0.73; 95% CI, 0.57 to 0.93; =0.01) and death (aHR, 0.62; 95% CI, 0.51 to 0.75;
ISSN:2641-7650
2641-7650
DOI:10.34067/KID.0001182019