Xuanfei Baidu Decoction reduces acute lung injury by regulating infiltration of neutrophils and macrophages via PD-1/IL17A pathway

The pathogenic hyper-inflammatory response has been revealed as the major cause of the severity and death of the Corona Virus Disease 2019 (COVID-19). Xuanfei Baidu Decoction (XFBD) as one of the “three medicines and three prescriptions” for the clinically effective treatment of COVID-19 in China, s...

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Published in:	Pharmacological research 2022-02, Vol.176, p.106083-106083, Article 106083
Main Authors:	Wang, Yuying, Wang, Xi, Li, Yixuan, Xue, Zhifeng, Shao, Rui, Li, Lin, Zhu, Yan, Zhang, Han, Yang, Jian
Format:	Article
Language:	English
Subjects:	Acute lung injury Acute Lung Injury - drug therapy Acute Lung Injury - metabolism Animals Cell Line China COVID-19 COVID-19 - metabolism COVID-19 Drug Treatment Cytokines - metabolism Drugs, Chinese Herbal - pharmacology Interleukin-17 - metabolism Leukocyte Count - methods Macrophages - drug effects Macrophages - metabolism Male Mice Mice, Inbred C57BL Neutrophils - drug effects Neutrophils - metabolism PD-1/IL17A pathway Programmed Cell Death 1 Receptor - metabolism RAW 264.7 Cells Signal Transduction - drug effects Systematic network pharmacological analysis Xuanfei Baidu Decoction
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