Potential Inhibitors Targeting Escherichia coli UDP-N-Acetylglucosamine Enolpyruvyl Transferase (MurA): An Overview

• Published in: Indian journal of microbiology 2022-03, Vol.62 (1), p.11-22
• Main Authors: Raina, Diksha, Kumar, Chetan, Kumar, Vinod, Khan, Inshad Ali, Saran, Saurabh
• Format: Article
• Language: English
• Subjects: Antibiotic resistance; Antibiotics; Antiinfectives and antibacterials; Antimicrobial agents; Biomedical and Life Sciences; Biosynthesis; Cell walls; Chemical synthesis; Clinical trials; E coli; Enzymes; Escherichia coli; Inhibitors; Life Sciences; Medical Microbiology; Microbiology; N-Acetylglucosamine; Penicillin; Peptidoglycans; Review; Review Article
• ISSN: 0046-8991; 0973-7715
• DOI: 10.1007/s12088-021-00988-6

Antibiotic resistance is one of the biggest challenges that is escalating and affecting humanity across the globe. To overcome this increasing burden of resistance, discovering novel hits by targeting the enzymes involved in peptidoglycan (murein) biosynthesis has always been considered better in antimicrobial drug discovery. UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) enzyme has been identified as essential for Escherichia coli survival and catalyzes the early-stage step in bacterial cell wall synthesis. The present article gives a brief overview of the role of enzymes in peptidoglycan synthesis and MurA enzyme (previously known as MurZ in E. coli ), in particular, including its structural and active site features. This review also provides an insight into the current knowledge of the reported MurA inhibitors, their mechanism of action and drawbacks of these hits that hinder their clinical trials, which would be helpful for synthesis and discovering potent molecules.