Post COVID-19 vaccine deaths - Singapore’s early experience

Singapore has been using mRNA vaccines developed by Pfizer-BioNTech and Moderna as part of the nation’s COVID vaccination program since 30 December 2020. From 1 February 2021–30 June 2021, a total of 34 deaths that occurred within 72 h of the deceased receiving their COVID-19 vaccination were referr...

Full description

Saved in:
Bibliographic Details
Published in:Forensic science international 2022-03, Vol.332, p.111199-111199, Article 111199
Main Authors: YEO, Audrey, KUEK, Benjamin, LAU, Mandy, TAN, Shi Rui, CHAN, Shijia
Format: Article
Language:English
Subjects:
Anaphylaxis
Autopsies
Blood clots
Boundaries
C-reactive protein
Complications
Contact tracing
Coronaviruses
COVID-19
COVID-19 vaccination
COVID-19 vaccines
Disease transmission
Drug dosages
Early experience
Fatalities
Forensic pathology
Forensic science
Forensic sciences
Heart diseases
Immunization
Immunoglobulin E
Mortality
mRNA
Myocarditis
Pericarditis
Quarantine
Severe acute respiratory syndrome coronavirus 2
Singapore
Thrombosis
Tryptase
Vaccines
Viruses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Singapore has been using mRNA vaccines developed by Pfizer-BioNTech and Moderna as part of the nation’s COVID vaccination program since 30 December 2020. From 1 February 2021–30 June 2021, a total of 34 deaths that occurred within 72 h of the deceased receiving their COVID-19 vaccination were referred to the Forensic Medicine Division of the Health Sciences Authority of Singapore. Autopsies, histological sampling and ancillary investigations consisting of total tryptase level, Immunoglobulin E (IgE), and C-reactive Protein (CRP), were performed on 29 of these cases. Our study has shown no definite causative relationship between the mRNA vaccination and deaths of individuals who died within 72 h after receiving the vaccination, in particular with regards to anaphylactic reactions, myocarditis and pericarditis, and thrombotic complications. Further studies may consider increasing the incident time frame from 72 h to seven days post-vaccination or longer to include any potential delayed presentation of adverse effects. •Death or collapses within 72 h post-mRNA COVID-19 vaccination were investigated.•No definite causative relationship between mRNA vaccination and deaths were found.•Further studies to consider increasing timeframe to include delayed adverse effects.
ISSN:0379-0738
1872-6283
1872-6283
DOI:10.1016/j.forsciint.2022.111199