Osteoconductive Effect of a Nanocomposite Membrane Treated with UV Radiation

Modulation of the bio-regenerative characteristics of materials is an indispensable requirement in tissue engineering. Particularly, in bone tissue engineering, the promotion of the osteoconductive phenomenon determines the elemental property of a material be used therapeutically. In addition to the...

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Bibliographic Details
Published in:Polymers 2022-01, Vol.14 (2), p.289
Main Authors: Olguín, Yusser, Acuna-Mendoza, Soledad, Otero, Carolina, Acevedo, Cristian A, Covarrubias, Cristian
Format: Article
Language:English
Subjects:
Animals
Biomedical materials
Chitosan
Communication
Composite materials
Gelatin
Hydroxyapatite
Membranes
Nanocomposites
Nanoparticles
Protective coatings
Scanning electron microscopy
Statistical analysis
Surface structure
Tissue engineering
Titanium
Titanium oxides
Ultraviolet radiation
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Summary:Modulation of the bio-regenerative characteristics of materials is an indispensable requirement in tissue engineering. Particularly, in bone tissue engineering, the promotion of the osteoconductive phenomenon determines the elemental property of a material be used therapeutically. In addition to the chemical qualities of the constituent materials, the three-dimensional surface structure plays a fundamental role that various methods are expected to modulate in a number of ways, one most promising of which is the use of different types of radiation. In the present manuscript, we demonstrate in a calvarial defect model, that treatment with ultraviolet irradiation allows modification of the osteoconductive characteristics in a biomaterial formed by gelatin and chitosan, together with the inclusion of hydroxyapatite and titanium oxide nanoparticles.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14020289