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Long-Term Aspirin Use and Self-Reported Walking Speed in Older Men: The Physicians' Health Study

Mobility limitation is a component of frailty that shares a bidirectional relationship with cardiovascular disease (CVD). Data are limited on the role of established CVD prevention therapies, such as aspirin, for prevention of frailty and mobility limitation. Examine the association between long-ter...

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Bibliographic Details
Published in:The Journal of frailty & aging 2022-01, Vol.11 (1), p.12-17
Main Authors: Orkaby, A R, Dufour, A B, Yang, L, Sesso, H D, Gaziano, J M, Djousse, L, Driver, J A, Travison, T G
Format: Article
Language:English
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Summary:Mobility limitation is a component of frailty that shares a bidirectional relationship with cardiovascular disease (CVD). Data are limited on the role of established CVD prevention therapies, such as aspirin, for prevention of frailty and mobility limitation. Examine the association between long-term aspirin use and walking speed. Prospective cohort of 14,315 men who participated in the Physicians' Health Study I, a completed randomized controlled trial of aspirin (1982-1988), with extended post-trial follow-up. Annual questionnaires collected data on aspirin use, lifestyle and other factors. Average annual aspirin use was categorized for each participant: ≤60 days/year and >60 days/year. Mobility was defined according to self-reported walking pace, categorized as: don't walk regularly (reference), easy/casual 60 days/year was associated with drinking alcohol, smoking, hypertension, heart disease and stroke, while ≤60 days/year was associated with anticoagulation use and bleeding history. In all, 13% reported not walking regularly, 12% walked
ISSN:2260-1341
2273-4309
DOI:10.14283/jfa.2021.36