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Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration
Purpose The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular...
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| Published in: | Graefe's archive for clinical and experimental ophthalmology 2022-03, Vol.260 (3), p.781-789 |
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| creator | Cozzi, Mariano Monteduro, Davide Parrulli, Salvatore Ristoldo, Federica Corvi, Federico Zicarelli, Federico Staurenghi, Giovanni Invernizzi, Alessandro |
| description | Purpose
The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD).
Methods
In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity.
Results
Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 (
P
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| doi_str_mv | 10.1007/s00417-021-05384-w |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8850287</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2570108998</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-ed3f44ccd5e651407d5ccada479bdac82d701fc93babb85db950cc3e9ac0c5e3</originalsourceid><addsrcrecordid>eNp9kUtv1DAUhS0EokPhD7BAltiwCfg5TjZIqCoPqRIsuujOcq5vZlySuNjOjPrvMaSUx4KVpXu_c3yPDiHPOXvNGTNvMmOKm4YJ3jAtW9UcH5ANV1I3homrh2TDTF21UlydkCc5X7PKS80fkxOpVMeV2G7I9CUh7GOKwbuRwohDoWUf4OuMOVOIKeHoCmZ6DGVPfcjoMlIHJRxCuaVhpjPGg8uwjC5Rt8NmFXg6uXXmcYczJldCnJ-SR4MbMz67e0_J5fvzy7OPzcXnD5_O3l00oIwqDXo5KAXgNW41V8x4DeC8U6brvYNWeMP4AJ3sXd-32vedZgASOwcMNMpT8na1vVn6CT3gXJIb7U0Kk0u3Nrpg_97MYW938WDbVjPRmmrw6s4gxW8L5mKnkAHH0dW0S7ZC1wNY23VtRV_-g17HJc01nRVb0fGtkFxXSqwUpJhzwuH-GM7sjzLtWqatZdqfZdpjFb34M8a95Fd7FZArkOtq3mH6_fd_bL8DC2-v4g</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2629162315</pqid></control><display><type>article</type><title>Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration</title><source>Springer Nature</source><creator>Cozzi, Mariano ; Monteduro, Davide ; Parrulli, Salvatore ; Ristoldo, Federica ; Corvi, Federico ; Zicarelli, Federico ; Staurenghi, Giovanni ; Invernizzi, Alessandro</creator><creatorcontrib>Cozzi, Mariano ; Monteduro, Davide ; Parrulli, Salvatore ; Ristoldo, Federica ; Corvi, Federico ; Zicarelli, Federico ; Staurenghi, Giovanni ; Invernizzi, Alessandro</creatorcontrib><description>Purpose
The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD).
Methods
In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity.
Results
Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 (
P
< 0.05) and a subsequent decrease of the cleft height after treatment with anti-VEGF agents (
P
= 0.004). A similar significant trend was observed for the greatest prechoroidal cleft height and width, obtained assessing the whole OCT raster. In the multivariate analysis, the cleft height was significantly affected by both time (
P
= 0.001) and PED height (
P
< 0.0001). By contrast, the effect of fibrovascular tissue size within the PED was not significant. Visual acuity did not correlate with prechoroidal cleft size.
Conclusion
Prechoroidal cleft increased in association with MNV reactivation and decreased after treatment. Our results suggest that prechoroidal cleft could represent an accumulation of fluid actively exudating from the MNV and should be considered a sign of nAMD activity.</description><identifier>ISSN: 0721-832X</identifier><identifier>EISSN: 1435-702X</identifier><identifier>DOI: 10.1007/s00417-021-05384-w</identifier><identifier>PMID: 34491426</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Acuity ; Age ; Angiogenesis Inhibitors - therapeutic use ; Fluorescein Angiography ; Humans ; Intravitreal Injections ; Macular degeneration ; Macular Degeneration - diagnosis ; Medicine ; Medicine & Public Health ; Multivariate analysis ; Ophthalmology ; Patients ; Retinal Disorders ; Retinal Pigment Epithelium ; Retrospective Studies ; Tomography, Optical Coherence ; Vascular endothelial growth factor ; Vascularization ; Wet Macular Degeneration - complications ; Wet Macular Degeneration - diagnosis ; Wet Macular Degeneration - drug therapy</subject><ispartof>Graefe's archive for clinical and experimental ophthalmology, 2022-03, Vol.260 (3), p.781-789</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-ed3f44ccd5e651407d5ccada479bdac82d701fc93babb85db950cc3e9ac0c5e3</citedby><cites>FETCH-LOGICAL-c474t-ed3f44ccd5e651407d5ccada479bdac82d701fc93babb85db950cc3e9ac0c5e3</cites><orcidid>0000-0003-3400-1987</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34491426$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cozzi, Mariano</creatorcontrib><creatorcontrib>Monteduro, Davide</creatorcontrib><creatorcontrib>Parrulli, Salvatore</creatorcontrib><creatorcontrib>Ristoldo, Federica</creatorcontrib><creatorcontrib>Corvi, Federico</creatorcontrib><creatorcontrib>Zicarelli, Federico</creatorcontrib><creatorcontrib>Staurenghi, Giovanni</creatorcontrib><creatorcontrib>Invernizzi, Alessandro</creatorcontrib><title>Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration</title><title>Graefe's archive for clinical and experimental ophthalmology</title><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><description>Purpose
The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD).
Methods
In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity.
Results
Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 (
P
< 0.05) and a subsequent decrease of the cleft height after treatment with anti-VEGF agents (
P
= 0.004). A similar significant trend was observed for the greatest prechoroidal cleft height and width, obtained assessing the whole OCT raster. In the multivariate analysis, the cleft height was significantly affected by both time (
P
= 0.001) and PED height (
P
< 0.0001). By contrast, the effect of fibrovascular tissue size within the PED was not significant. Visual acuity did not correlate with prechoroidal cleft size.
Conclusion
Prechoroidal cleft increased in association with MNV reactivation and decreased after treatment. Our results suggest that prechoroidal cleft could represent an accumulation of fluid actively exudating from the MNV and should be considered a sign of nAMD activity.</description><subject>Acuity</subject><subject>Age</subject><subject>Angiogenesis Inhibitors - therapeutic use</subject><subject>Fluorescein Angiography</subject><subject>Humans</subject><subject>Intravitreal Injections</subject><subject>Macular degeneration</subject><subject>Macular Degeneration - diagnosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multivariate analysis</subject><subject>Ophthalmology</subject><subject>Patients</subject><subject>Retinal Disorders</subject><subject>Retinal Pigment Epithelium</subject><subject>Retrospective Studies</subject><subject>Tomography, Optical Coherence</subject><subject>Vascular endothelial growth factor</subject><subject>Vascularization</subject><subject>Wet Macular Degeneration - complications</subject><subject>Wet Macular Degeneration - diagnosis</subject><subject>Wet Macular Degeneration - drug therapy</subject><issn>0721-832X</issn><issn>1435-702X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp9kUtv1DAUhS0EokPhD7BAltiwCfg5TjZIqCoPqRIsuujOcq5vZlySuNjOjPrvMaSUx4KVpXu_c3yPDiHPOXvNGTNvMmOKm4YJ3jAtW9UcH5ANV1I3homrh2TDTF21UlydkCc5X7PKS80fkxOpVMeV2G7I9CUh7GOKwbuRwohDoWUf4OuMOVOIKeHoCmZ6DGVPfcjoMlIHJRxCuaVhpjPGg8uwjC5Rt8NmFXg6uXXmcYczJldCnJ-SR4MbMz67e0_J5fvzy7OPzcXnD5_O3l00oIwqDXo5KAXgNW41V8x4DeC8U6brvYNWeMP4AJ3sXd-32vedZgASOwcMNMpT8na1vVn6CT3gXJIb7U0Kk0u3Nrpg_97MYW938WDbVjPRmmrw6s4gxW8L5mKnkAHH0dW0S7ZC1wNY23VtRV_-g17HJc01nRVb0fGtkFxXSqwUpJhzwuH-GM7sjzLtWqatZdqfZdpjFb34M8a95Fd7FZArkOtq3mH6_fd_bL8DC2-v4g</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Cozzi, Mariano</creator><creator>Monteduro, Davide</creator><creator>Parrulli, Salvatore</creator><creator>Ristoldo, Federica</creator><creator>Corvi, Federico</creator><creator>Zicarelli, Federico</creator><creator>Staurenghi, Giovanni</creator><creator>Invernizzi, Alessandro</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3400-1987</orcidid></search><sort><creationdate>20220301</creationdate><title>Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration</title><author>Cozzi, Mariano ; Monteduro, Davide ; Parrulli, Salvatore ; Ristoldo, Federica ; Corvi, Federico ; Zicarelli, Federico ; Staurenghi, Giovanni ; Invernizzi, Alessandro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-ed3f44ccd5e651407d5ccada479bdac82d701fc93babb85db950cc3e9ac0c5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acuity</topic><topic>Age</topic><topic>Angiogenesis Inhibitors - therapeutic use</topic><topic>Fluorescein Angiography</topic><topic>Humans</topic><topic>Intravitreal Injections</topic><topic>Macular degeneration</topic><topic>Macular Degeneration - diagnosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multivariate analysis</topic><topic>Ophthalmology</topic><topic>Patients</topic><topic>Retinal Disorders</topic><topic>Retinal Pigment Epithelium</topic><topic>Retrospective Studies</topic><topic>Tomography, Optical Coherence</topic><topic>Vascular endothelial growth factor</topic><topic>Vascularization</topic><topic>Wet Macular Degeneration - complications</topic><topic>Wet Macular Degeneration - diagnosis</topic><topic>Wet Macular Degeneration - drug therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cozzi, Mariano</creatorcontrib><creatorcontrib>Monteduro, Davide</creatorcontrib><creatorcontrib>Parrulli, Salvatore</creatorcontrib><creatorcontrib>Ristoldo, Federica</creatorcontrib><creatorcontrib>Corvi, Federico</creatorcontrib><creatorcontrib>Zicarelli, Federico</creatorcontrib><creatorcontrib>Staurenghi, Giovanni</creatorcontrib><creatorcontrib>Invernizzi, Alessandro</creatorcontrib><collection>SpringerOpen</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cozzi, Mariano</au><au>Monteduro, Davide</au><au>Parrulli, Salvatore</au><au>Ristoldo, Federica</au><au>Corvi, Federico</au><au>Zicarelli, Federico</au><au>Staurenghi, Giovanni</au><au>Invernizzi, Alessandro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration</atitle><jtitle>Graefe's archive for clinical and experimental ophthalmology</jtitle><stitle>Graefes Arch Clin Exp Ophthalmol</stitle><addtitle>Graefes Arch Clin Exp Ophthalmol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>260</volume><issue>3</issue><spage>781</spage><epage>789</epage><pages>781-789</pages><issn>0721-832X</issn><eissn>1435-702X</eissn><abstract>Purpose
The purpose of this study was to investigate the structural variations of the hyporeflective pocket of fluid (prechoroidal cleft) located between Bruch’s membrane and the hyperreflective material within the pigment epithelial detachment (PED) in patients with neovascular age-related macular degeneration (nAMD).
Methods
In this retrospective, observational case series study, patients diagnosed with nAMD and prechoroidal cleft associated with other activity signs of the macular neovascularization (MNV) were included. Structural optical coherence tomography (OCT) scans were evaluated to obtain anatomical measurements of prechoroidal cleft and PED at three different visits (T0, inactive MNV; T1, active MNV; T2, treated inactive MNV). The variations in size of the cleft and the PED were correlated with nAMD activity.
Results
Twenty-nine eyes from 27 patients were included. The subfoveal measurements showed a significant increase of prechoroidal cleft height and width from T0 to T1 (
P
< 0.05) and a subsequent decrease of the cleft height after treatment with anti-VEGF agents (
P
= 0.004). A similar significant trend was observed for the greatest prechoroidal cleft height and width, obtained assessing the whole OCT raster. In the multivariate analysis, the cleft height was significantly affected by both time (
P
= 0.001) and PED height (
P
< 0.0001). By contrast, the effect of fibrovascular tissue size within the PED was not significant. Visual acuity did not correlate with prechoroidal cleft size.
Conclusion
Prechoroidal cleft increased in association with MNV reactivation and decreased after treatment. Our results suggest that prechoroidal cleft could represent an accumulation of fluid actively exudating from the MNV and should be considered a sign of nAMD activity.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34491426</pmid><doi>10.1007/s00417-021-05384-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3400-1987</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Graefe's archive for clinical and experimental ophthalmology, 2022-03, Vol.260 (3), p.781-789 |
| issn | 0721-832X 1435-702X |
| language | eng |
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| source | Springer Nature |
| subjects | Acuity Age Angiogenesis Inhibitors - therapeutic use Fluorescein Angiography Humans Intravitreal Injections Macular degeneration Macular Degeneration - diagnosis Medicine Medicine & Public Health Multivariate analysis Ophthalmology Patients Retinal Disorders Retinal Pigment Epithelium Retrospective Studies Tomography, Optical Coherence Vascular endothelial growth factor Vascularization Wet Macular Degeneration - complications Wet Macular Degeneration - diagnosis Wet Macular Degeneration - drug therapy |
| title | Prechoroidal cleft thickness correlates with disease activity in neovascular age-related macular degeneration |
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