Association of plant-based diet index with prostate cancer risk

Plant-based diets are associated with multiple health benefits and a favorable environmental impact. For prostate cancer, previous studies suggest a beneficial role of specific plant-based foods (e.g., tomatoes) and a potentially harmful role of specific animal-based foods (e.g., meat, dairy). Howev...

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Published in:The American journal of clinical nutrition 2022-03, Vol.115 (3), p.662-670
Main Authors: Loeb, Stacy, Fu, Benjamin C, Bauer, Scott R, Pernar, Claire H, Chan, June M, Van Blarigan, Erin L, Giovannucci, Edward L, Kenfield, Stacey A, Mucci, Lorelei A
Format: Article
Language:English
Subjects:
Animal-based foods
Animals
Dairy products
Diet
Diet, Vegetarian
dietary patterns
Environmental impact
epidemiology
Follow-Up Studies
Food
Food plants
Health risks
Humans
Male
Meat
Medical personnel
Metastases
nutrition
Original Research Communications
plant-based diet
Plant-based foods
Plants
Prospective Studies
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - etiology
Risk
Statistical models
Tomatoes
Vegan
Veganism
Vegetarian diet
Vegetarianism
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description Plant-based diets are associated with multiple health benefits and a favorable environmental impact. For prostate cancer, previous studies suggest a beneficial role of specific plant-based foods (e.g., tomatoes) and a potentially harmful role of specific animal-based foods (e.g., meat, dairy). However, less is known about plant-based dietary patterns. We sought to examine the relation between plant-based diet indices and prostate cancer risk, including clinically relevant disease. This was a prospective cohort study including 47,239 men in the Health Professionals Follow-Up Study (1986–2014). Overall and healthful plant-based diet indices were calculated from FFQs. Cox proportional hazards models were used to estimate HRs and 95% CIs to examine the risk of incident prostate cancer (total and by clinical category), among men ages
doi_str_mv 10.1093/ajcn/nqab365
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For prostate cancer, previous studies suggest a beneficial role of specific plant-based foods (e.g., tomatoes) and a potentially harmful role of specific animal-based foods (e.g., meat, dairy). However, less is known about plant-based dietary patterns. We sought to examine the relation between plant-based diet indices and prostate cancer risk, including clinically relevant disease. This was a prospective cohort study including 47,239 men in the Health Professionals Follow-Up Study (1986–2014). Overall and healthful plant-based diet indices were calculated from FFQs. Cox proportional hazards models were used to estimate HRs and 95% CIs to examine the risk of incident prostate cancer (total and by clinical category), among men ages &lt;65 and ≥65 y. Of the 47,239 men, 6655 men were diagnosed with prostate cancer over follow-up, including 515 with advanced-stage disease at diagnosis, 956 with lethal disease (metastasis or death), and 806 prostate cancer deaths. Greater overall plant-based consumption was associated with a significantly lower risk of fatal prostate cancer (HR: 0.81; 95% CI: 0.64, 1.01; P-trend = 0.04). In men aged &lt;65, a higher plant-based diet index was associated with a lower risk of advanced, lethal, and fatal prostate cancer. Moreover, greater consumption of a healthful plant-based diet was associated with lower risks of total (HR: 0.84; 95% CI: 0.73, 0.98; P-trend = 0.046) and lethal prostate cancer (HR: 0.56; 95% CI: 0.34, 0.94; P-trend = 0.03) at age &lt;65. There were no associations between overall or healthful plant-based diet indices with prostate cancer among men ≥65 y. Fewer than 1% of participants followed a strict vegetarian or vegan diet. 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source ScienceDirect Journals
subjects Animal-based foods
Animals
Dairy products
Diet
Diet, Vegetarian
dietary patterns
Environmental impact
epidemiology
Follow-Up Studies
Food
Food plants
Health risks
Humans
Male
Meat
Medical personnel
Metastases
nutrition
Original Research Communications
plant-based diet
Plant-based foods
Plants
Prospective Studies
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - etiology
Risk
Statistical models
Tomatoes
Vegan
Veganism
Vegetarian diet
Vegetarianism
title Association of plant-based diet index with prostate cancer risk
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