Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders

Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity via the activation of engineered receptors that are pharmacologically selective to endogenous or exogenous ligands. With recent advances in therapeutic gene delivery, chemogenetics is poised to support novel in...

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Bibliographic Details
Published in:Molecular therapy 2022-03, Vol.30 (3), p.990-1005
Main Authors: Song, Jingwei, Patel, Ruchit V., Sharif, Massoud, Ashokan, Anagha, Michaelides, Michael
Format: Article
Language:English
Subjects:
chemogenetics
DREADDs
gene delivery
gene therapy
Genetic Therapy
Ligands
neuromodulation
neurotherapeutics
Review
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Summary:Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity via the activation of engineered receptors that are pharmacologically selective to endogenous or exogenous ligands. With recent advances in therapeutic gene delivery, chemogenetics is poised to support novel interventions against neuropsychiatric diseases and disorders. To evaluate its translational potential, we performed a scoping review of applications of chemogenetics that led to the reversal of molecular and behavioral deficits in studies relevant to neuropsychiatric diseases and disorders. In this review, we present these findings and discuss the potential and challenges for using chemogenetics as a precision medicine-based neuromodulation strategy. [Display omitted] Recent advances in neurological gene therapy enable delivery of chemogenetic receptors for pharmacologically controlled neuromodulation. Song et al. perform a scoping review of all existing applications of chemogenetic systems in models of neuropsychiatric diseases and disorders to reveal major areas of consideration for future translation.
ISSN:1525-0016
1525-0024
DOI:10.1016/j.ymthe.2021.11.019