Mid-life epigenetic age, neuroimaging brain age, and cognitive function: coronary artery risk development in young adults (CARDIA) study

The proportion of aging populations affected by dementia is increasing. There is an urgent need to identify biological aging markers in mid-life before symptoms of age-related dementia present for early intervention to delay the cognitive decline and the onset of dementia. In this cohort study invol...

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Published in:Aging (Albany, NY.) NY.), 2022-02, Vol.14 (4), p.1691-1712
Main Authors: Zheng, Yinan, Habes, Mohamad, Gonzales, Mitzi, Pomponio, Raymond, Nasrallah, Ilya, Khan, Sadiya, Vaughan, Douglas E, Davatzikos, Christos, Seshadri, Sudha, Launer, Lenore, Sorond, Farzaneh, Sedaghat, Sanaz, Wainwright, Derek, Baccarelli, Andrea, Sidney, Stephen, Bryan, Nick, Greenland, Philip, Lloyd-Jones, Donald, Yaffe, Kristine, Hou, Lifang
Format: Article
Language:English
Subjects:
Aging - genetics
Biomarkers
Brain - diagnostic imaging
Cognition
Cognitive Dysfunction - diagnostic imaging
Cognitive Dysfunction - genetics
Cohort Studies
Coronary Vessels
Dementia
Epigenesis, Genetic
Humans
Longitudinal Studies
Neuroimaging
Research Paper
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Summary:The proportion of aging populations affected by dementia is increasing. There is an urgent need to identify biological aging markers in mid-life before symptoms of age-related dementia present for early intervention to delay the cognitive decline and the onset of dementia. In this cohort study involving 1,676 healthy participants (mean age 40) with up to 15 years of follow up, we evaluated the associations between cognitive function and two classes of novel biological aging markers: blood-based epigenetic aging and neuroimaging-based brain aging. Both accelerated epigenetic aging and brain aging were prospectively associated with worse cognitive outcomes. Specifically, every year faster epigenetic or brain aging was on average associated with 0.19-0.28 higher (worse) Stroop score, 0.04-0.05 lower (worse) RAVLT score, and 0.23-0.45 lower (worse) DSST (all false-discovery-rate-adjusted p
ISSN:1945-4589
1945-4589
DOI:10.18632/aging.203918