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Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators
The segment-specific regulatory domains of the Bithorax complex (BX-C), which consists of three homeotic genes Ubx, abd-A and Abd-B , are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for highe...
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| Published in: | Doklady. Biochemistry and biophysics 2022-02, Vol.502 (1), p.21-24 |
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| container_end_page | 24 |
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| container_title | Doklady. Biochemistry and biophysics |
| container_volume | 502 |
| creator | Kyrchanova, O. V. Postika, N. Y. Sokolov, V. V. Georgiev, P. G. |
| description | The segment-specific regulatory domains of the
Bithorax
complex (BX-C), which consists of three homeotic genes
Ubx, abd-A
and
Abd-B
, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the
Abd-B
regulatory region. In this study, it was shown that fragments of the
Fab-3
and
Fab-4
boundaries of the
abd-A
regulatory region, containing CTCF binding sites, are not effective insulators. |
| doi_str_mv | 10.1134/S1607672922010069 |
| format | article |
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Bithorax
complex (BX-C), which consists of three homeotic genes
Ubx, abd-A
and
Abd-B
, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the
Abd-B
regulatory region. In this study, it was shown that fragments of the
Fab-3
and
Fab-4
boundaries of the
abd-A
regulatory region, containing CTCF binding sites, are not effective insulators.</description><identifier>ISSN: 1607-6729</identifier><identifier>EISSN: 1608-3091</identifier><identifier>DOI: 10.1134/S1607672922010069</identifier><identifier>PMID: 35275301</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Animals ; Binding Sites ; Biochemistry ; Biochemistry, Biophysics, and Molecular Biology ; Biological and Medical Physics ; Biomedical and Life Sciences ; Biophysics ; Boundaries ; CCCTC-Binding Factor - genetics ; CCCTC-Binding Factor - metabolism ; Drosophila melanogaster - genetics ; Drosophila melanogaster - metabolism ; Drosophila Proteins - genetics ; Drosophila Proteins - metabolism ; Genes, Homeobox ; Homeodomain Proteins - genetics ; Homeodomain Proteins - metabolism ; Insulator Elements ; Life Sciences ; Molecular Biology ; Transcription Factors - metabolism</subject><ispartof>Doklady. Biochemistry and biophysics, 2022-02, Vol.502 (1), p.21-24</ispartof><rights>Pleiades Publishing, Ltd. 2022. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 502, pp. 21–24. © Pleiades Publishing, Ltd., 2022. This article is an open access publication. Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 502, pp. 28–31.</rights><rights>2022. Pleiades Publishing, Ltd.</rights><rights>Pleiades Publishing, Ltd. 2022. ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 502, pp. 21–24. © Pleiades Publishing, Ltd., 2022. This article is an open access publication. Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 502, pp. 28–31. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Pleiades Publishing, Ltd. 2022, ISSN 1607-6729, Doklady Biochemistry and Biophysics, 2022, Vol. 502, pp. 21–24. © Pleiades Publishing, Ltd., 2022. This article is an open access publication.Russian Text © The Author(s), 2022, published in Doklady Rossiiskoi Akademii Nauk. Nauki o Zhizni, 2022, Vol. 502, pp. 28–31.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c422t-2c1c62fc5caf1d5c693b507e3bf14de25d79c70cc3d1a0178b63f74650eac1793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35275301$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kyrchanova, O. V.</creatorcontrib><creatorcontrib>Postika, N. Y.</creatorcontrib><creatorcontrib>Sokolov, V. V.</creatorcontrib><creatorcontrib>Georgiev, P. G.</creatorcontrib><title>Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators</title><title>Doklady. Biochemistry and biophysics</title><addtitle>Dokl Biochem Biophys</addtitle><addtitle>Dokl Biochem Biophys</addtitle><description>The segment-specific regulatory domains of the
Bithorax
complex (BX-C), which consists of three homeotic genes
Ubx, abd-A
and
Abd-B
, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the
Abd-B
regulatory region. In this study, it was shown that fragments of the
Fab-3
and
Fab-4
boundaries of the
abd-A
regulatory region, containing CTCF binding sites, are not effective insulators.</description><subject>Animals</subject><subject>Binding Sites</subject><subject>Biochemistry</subject><subject>Biochemistry, Biophysics, and Molecular Biology</subject><subject>Biological and Medical Physics</subject><subject>Biomedical and Life Sciences</subject><subject>Biophysics</subject><subject>Boundaries</subject><subject>CCCTC-Binding Factor - genetics</subject><subject>CCCTC-Binding Factor - metabolism</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - metabolism</subject><subject>Drosophila Proteins - genetics</subject><subject>Drosophila Proteins - metabolism</subject><subject>Genes, Homeobox</subject><subject>Homeodomain Proteins - genetics</subject><subject>Homeodomain Proteins - metabolism</subject><subject>Insulator Elements</subject><subject>Life Sciences</subject><subject>Molecular Biology</subject><subject>Transcription Factors - metabolism</subject><issn>1607-6729</issn><issn>1608-3091</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNp1kcFu1DAQhi1ERUvhAbggS1y4BDx2Em8uSG3apZUqcehythxnskmV2IvtVOUt-si4u2ULRVzskeebfzz_EPIO2CcAkX--hpLJUvKKcwaMldULcpSeFplgFbzcxjJ7yB-S1yHcMMYZF8UrcigKLgvB4IjcL71eT2hjoK6jsUe61E0mqLbtNsrpqZttq_2Ae-LMu-A2_TBqOuGorVvrENHT0yH2zus7WrtpM-IdXfU60ktrxrlFWq_qJb0eYtI58Uiti_S869DE4RYTFOZRR-fDG3LQ6THg28f7mHxfnq_qi-zq29fL-uQqMznnMeMGTMk7UxjdQVuYshJNwSSKpoO8RV60sjKSGSNa0AzkoilFJ_OyYKgNyEocky873c3cTNiaZIHXo9r4YdL-p3J6UH9n7NCrtbtViwokMEgCHx8FvPsxY4hqGoLBMRmCbg6Kl2IhoUxnQj88Q2_c7G0ab0vxqhBbCnaUSf4Gj93-M8DUw77VP_tONe__nGJf8XvBCeA7IKSUXaN_av1_1V9sObVs</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Kyrchanova, O. 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Bithorax
complex (BX-C), which consists of three homeotic genes
Ubx, abd-A
and
Abd-B
, are separated by boundaries that function as insulators. Most of the boundaries contain binding sites for the architectural protein CTCF, which is conserved for higher eukaryotes. As was shown previously, the CTCF sites determine the insulator activity of the boundaries of the
Abd-B
regulatory region. In this study, it was shown that fragments of the
Fab-3
and
Fab-4
boundaries of the
abd-A
regulatory region, containing CTCF binding sites, are not effective insulators.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><pmid>35275301</pmid><doi>10.1134/S1607672922010069</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Binding Sites Biochemistry Biochemistry, Biophysics, and Molecular Biology Biological and Medical Physics Biomedical and Life Sciences Biophysics Boundaries CCCTC-Binding Factor - genetics CCCTC-Binding Factor - metabolism Drosophila melanogaster - genetics Drosophila melanogaster - metabolism Drosophila Proteins - genetics Drosophila Proteins - metabolism Genes, Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Insulator Elements Life Sciences Molecular Biology Transcription Factors - metabolism |
| title | Fragments of the Fab-3 and Fab-4 Boundaries of the Drosophila melanogaster Bithorax Complex That Include CTCF Sites Are not Effective Insulators |
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