MR lung perfusion measurements in adolescents after congenital diaphragmatic hernia: correlation with spirometric lung function tests

Objectives To evaluate whether lung perfusion continues to be reduced in 10-year-old children after congenital diaphragmatic hernia (CDH) and whether lung perfusion values correlate with spirometric lung function measurements. Methods Fifty-four patients after CDH repair received dynamic contrast-en...

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Bibliographic Details
Published in:European radiology 2022-04, Vol.32 (4), p.2572-2580
Main Authors: Groß, Verena, Zahn, Katrin, Maurer, Kristina, Wessel, Lucas, Schaible, Thomas, Schoenberg, Stefan O., Weiß, Christel, Zoellner, Frank G., Weis, Meike
Format: Article
Language:English
Subjects:
Adolescent
Blood flow
Child
Children
Diagnostic Radiology
Diaphragm
Hernia
Hernias
Hernias, Diaphragmatic, Congenital
Humans
Imaging
Internal Medicine
Interventional Radiology
Ionizing radiation
Lung - pathology
Lungs
Magnetic resonance imaging
Medicine
Medicine & Public Health
Neuroradiology
Paediatric
Parameters
Perfusion
Radiation measurement
Radiology
Respiratory function
Respiratory Function Tests
Spirometry
Ultrasound
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Summary:Objectives To evaluate whether lung perfusion continues to be reduced in 10-year-old children after congenital diaphragmatic hernia (CDH) and whether lung perfusion values correlate with spirometric lung function measurements. Methods Fifty-four patients after CDH repair received dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI)-based lung perfusion measurements at the age of 10 years (10.2 ± 1.0 years). Additionally, a control group of 10 children has been examined according to the same protocol. Lung spirometry was additionally available in 43 patients of the CDH group. A comparison of ipsilateral and contralateral parameters was performed. Results Pulmonary blood flow (PBF) was reduced on the ipsilateral side in CDH patients (60.4 ± 23.8 vs. 93.3 ± 16.09 mL/100 mL/min; p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-021-08315-9