Epidemiology, clinical ramifications, and cellular pathogenesis of COVID-19 mRNA-vaccination-induced adverse cardiovascular outcomes: A state-of-the-heart review

The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccina...

Full description

Saved in:
Bibliographic Details
Published in:Biomedicine & pharmacotherapy 2022-05, Vol.149, p.112843-112843, Article 112843
Main Authors: Almas, Talal, Rehman, Sarah, Mansour, Eyad, Khedro, Tarek, Alansari, Ali, Malik, Jahanzeb, Alshareef, Norah, Nagarajan, Vikneswaran Raj, Al-Awaid, Abdulla Hussain, Alsufyani, Reema, Alsufyani, Majid, Rifai, Ali, Alzahrani, Ahlam, Nagarajan, Dhineswaran Raj, Abdullatif, Tala, Gunasaegaram, Varman, Alzadjali, Enaam, Subramanian, Arthi, Rahman, Abida, Sattar, Yasar, Galo, Jason, Virk, Hafeez Ul Hassan, Alraies, M. Chadi
Format: Article
Language:English
Subjects:
Coronavirus 2019 (COVID-19)
COVID-19 - epidemiology
COVID-19 - prevention & control
COVID-19 mRNA vaccine
COVID-19 myocarditis
COVID-19 perimyocarditis
COVID-19 Vaccines - adverse effects
Humans
Review
RNA, Messenger - genetics
SARS-CoV-2
Takotsubo syndrome
Vaccination - adverse effects
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The coronavirus disease 2019 (COVID-19) has overwhelming healthcare systems globally. To date, a myriad of therapeutic regimens has been employed in an attempt to curb the ramifications of a severe COVID-19 infection. Amidst the ongoing pandemic, the advent and efficacious uptake of COVID-19 vaccination has significantly reduced disease-related hospitalizations and mortality. Nevertheless, many side-effects are being reported after COVID-19 vaccinations and myocarditis is the most commonly reported sequelae post vaccination. Majority of these diseases are associated with COVID-19 mRNA vaccines. Various studies have established a temporal relationship between these complications, yet the causality and the underlying pathogenesis remain hypothetical. In this review, we aim to critically appraise the available literature regarding the cardiovascular side effects of the various mRNA vaccines and the associated pathophysiology. [Display omitted]
ISSN:0753-3322
1950-6007
DOI:10.1016/j.biopha.2022.112843